Melt-Derived Condensed Polymorphic Calcium Phosphate as Bone Substitute Material: An In Vitro Study


The calcium phosphate family of biomaterials includes numerous compounds that might find applicability in orthopedics and dentistry as implant materials. However, only calcium phosphates of higher Ca:P ratio such as hydroxyapatite and tricalcium phosphates have been exposed to extensive investigations. Reports on the biomedical application of calcium phosphates with lower Ca: P ratios are sparse. The condensed calcium phosphates ([Ca(PO3)(2)](n)-Ca:P=0.5) represent such material. In the present work, calcium polyphosphate (CPP) with Ca:P=0.5 was synthesized and CPP scaffolds were fabricated. The synthesized polymorphic CPP powder was characterized for its chemical prosperities using X-ray diffraction, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy techniques and the fabricated scaffolds were tested in MC3T3 (murine osteoblast) cells for their biocompatibility. Cell viability test results indicate that CPP did not exert cytotoxicity effect on the cells after being cultured 21 days. CPP sintered at 1100 degrees C showed better cell attachment and proliferation. The results obtained in the present work demonstrate the suitability of CPP as potential scaffold material for translocation of cells.



subject category

Materials Science


Balamurugan, A; El Mabrouk, K; Pina, S; Bousmina, MM; Ferreira, JMF

our authors


The authors would like to gratefully acknowledge Mr. Y. Belmamouni and Ms. M. Bricha, Inanotech, Mascir, Morocco, and Mr. A. H. S. Rebelo, Department of Ceramics and Glass and Engineering, University of Aveiro, Portugal, for their technical contributions. Thanks are also due to CICECO for the support and to the Portuguese Foundation for Science and Technology for the fellowship grant of S. P. (SFRH/BPD/64119/2009) and the Hassan II Academy of Science and Technology, Morocco.

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