resumo
This paper reviews the main applications of NMR metabolomics of blood and urine in disease research, over the last 5 years. The broad range of disease types addressed attests the increasing interest within the academic and medical communities to explore the recognised potential of metabolomics to (1) provide insight into underlying disease pathogenesis and (2) unveil new metabolic markers for disease diagnosis and follow up. Importantly, most recent studies reveal an increasing awareness of possible limitations and pitfalls of the metabolomics approach, together with efforts for improved study design and statistical validation, which are crucial requisites for the sound development of NMR metabolomics and its progress into the clinical setting. (C) 2013 Elsevier B.V. All rights reserved.
palavras-chave
NUCLEAR-MAGNETIC-RESONANCE; INFLAMMATORY-BOWEL-DISEASE; MAJOR DEPRESSIVE DISORDER; POLYCYSTIC-OVARY-SYNDROME; CHRONIC KIDNEY-DISEASE; H-1-NMR SPECTROSCOPY; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; BREAST-CANCER; METABONOMIC SIGNATURE
categoria
Chemistry; Pharmacology & Pharmacy
autores
Duarte, IF; Diaz, SO; Gil, AM
nossos autores
Ana Maria Pissarra Coelho Gil
Professor Associado com Agregação
Iola Melissa Fernandes Duarte
Investigador Principal
Sílvia de Oliveira Diaz
Estudante de doutoramentoagradecimentos
The authors acknowledge funding from the European Regional Development Fund-FEDER through the Competitive Factors Thematic Operational Programme-COMPETE and the Foundation for Science and Technology-FCT, Portugal (PEst-C/CTM/LA0011/2013). S.O.D. thanks FCT for the SFRH/BD/73343/2010 grant. The Portuguese National NMR Network (RNRMN), supported with FCT funds, is also acknowledged.