NMR metabolomics of human blood and urine in disease research
authors Duarte, IF; Diaz, SO; Gil, AM
nationality International
journal JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
author keywords NMR spectroscopy; Metabolomics; Blood; Urine; Disease
keywords NUCLEAR-MAGNETIC-RESONANCE; INFLAMMATORY-BOWEL-DISEASE; MAJOR DEPRESSIVE DISORDER; POLYCYSTIC-OVARY-SYNDROME; CHRONIC KIDNEY-DISEASE; H-1-NMR SPECTROSCOPY; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; BREAST-CANCER; METABONOMIC SIGNATURE
abstract This paper reviews the main applications of NMR metabolomics of blood and urine in disease research, over the last 5 years. The broad range of disease types addressed attests the increasing interest within the academic and medical communities to explore the recognised potential of metabolomics to (1) provide insight into underlying disease pathogenesis and (2) unveil new metabolic markers for disease diagnosis and follow up. Importantly, most recent studies reveal an increasing awareness of possible limitations and pitfalls of the metabolomics approach, together with efforts for improved study design and statistical validation, which are crucial requisites for the sound development of NMR metabolomics and its progress into the clinical setting. (C) 2013 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0731-7085
year published 2014
volume 93
beginning page 17
ending page 26
digital object identifier (doi) 10.1016/j.jpba.2013.09.025
web of science category Chemistry, Analytical; Pharmacology & Pharmacy
subject category Chemistry; Pharmacology & Pharmacy
unique article identifier WOS:000336416300003
link 24854435
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journal analysis (jcr 2019):
journal impact factor 3.209
5 year journal impact factor 3.132
category normalized journal impact factor percentile 66.748
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