CICECO » PDMS-SiO2-TiO2-CaO hybrid materials - Cytocompatibility and nanoscale surface features

authors	Almeida, JC; Wacha, A; Gomes, PS; Fernandes, MHR; Fernandes, MHV; Salvado, IMM
nationality	International
journal	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords	Sol-gel; Hybrid materials; Hydrophobicity; Cytocompatibility; Bone
keywords	NUCLEAR-MAGNETIC-RESONANCE; POLYDIMETHYLSILOXANE (PDMS)-CAO-SIO2 HYBRIDS; MESOPOROUS BIOACTIVE GLASSES; SILOXANE-OXIDE MATERIALS; SMALL-ANGLE SCATTERING; SOL-GEL MATERIALS; X-RAY-SCATTERING; STATE SI-29 NMR; CELL-ADHESION; STRUCTURAL-CHARACTERIZATION
abstract	Two PDMS-SiO2-TiO2-Cao porous hybrid materials were prepared using the same base composition, precursors, and solvents, but following two different sol-gel procedures, based on the authors' previous works where for the first time, in this hybrid system, calcium acetate was used as calcium source. The two different procedures resulted in monolithic materials with different structures, microstructures, and surface wettability. Even though both are highly hydrophobic (contact angles of 127.2 degrees and 150.6 degrees), and present different filling regimes due to different surface topographies, they have demonstrated to be-cytocompatible when tested with human osteoblastic cells, against the accepted idea that high-hydrophobic surfaces are not suitable to cell adhesion and proliferation. At the nanoscale, the existence of hydrophilic silica domains containing calcium, where water molecules are physisorbed, is assumed to support this capability, as discussed. (C) 2016 Elsevier B.V. All rights reserved.
publisher	ELSEVIER SCIENCE BV
issn	0928-4931
year published	2016
volume	64
beginning page	74
ending page	86
digital object identifier (doi)	10.1016/j.msec.2016.03.071
web of science category	Materials Science, Biomaterials
subject category	Materials Science
unique article identifier	WOS:000376547700009