Lanthanide(III) Complexes of 4,10-Bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H(6)do2a2p) in Solution and in the Solid State: Structural Studies Along the Series


Complexes of 4,10-bis(phosphonomethyl)-1,4,7,10-tetraazacyclodo-decane-1,7-diacetic acid (trans-H(6)do2a2p, H6L) with transition metal and lanthanide(III) ions were investigated. The stability constant values of the divalent and trivalent metal-ion complexes are between the corresponding values of H(4)dota and H(8)dotp complexes, as a consequence of the ligand basicity. The solid-state structures of the ligand and of nine lanthanide(III) complexes were determined by X-ray diffraction. All the complexes are present as twisted-square-antiprismatic isomers and their structures can be divided into two series. The first one involves nona-coordinated complexes of the large lanthanide(III) ions (Ce, Nd, Sm) with a coordinated water molecule. In the series of Sm, Eu, Tb, Dy, Er, Yb, the complexes are octa-coordinated only by the ligand donor atoms and their coordination cages are more irregular. The formation kinetics and the acid-assisted dissociation of several Ln(III)-H6L complexes were investigated at different temperatures and compared with analogous data for complexes of other dota-like ligands. The [Ce(L)(H2O)](3-) complex is the most kinetically inert among complexes of the investigated lanthanide(III) ions (Ce, Eu, Gd, Yb). Among mixed phosphonate acetate dota analogues, kinetic inertness of the cerium(III) complexes is increased with a higher number of phosphonate arms in the ligand, whereas the opposite is true for europium(III) complexes. According to the H-1 NMR spectroscopic pseudo-contact shifts for the Ce-Eu and Tb-Yb series, the solution structures of the complexes reflect the structures of the [Ce(HL)(H2O)](2-) and [Yb(HL)](2-) anions, respectively, found in the solid state. However, these solution NMR spectroscopic studies showed that there is no unambiguous relation between P-31/H-1 lanthanide-induced shift (LIS) values and coordination of water in the complexes; the values rather express a relative position of the central ions between the N-4 and O-4 planes.



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Campello, MPC; Lacerda, S; Santos, IC; Pereira, GA; Geraldes, CFGC; Kotek, J; Hermann, P; Vanek, J; Lubal, P; Kubicek, V; Toth, E; Santos, I



This work was financially supported by the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal (project POCTI/CBO/35859/99 (for I.S.), PTDC/QUI/70063/2006 (for C.F.G.C.G.), and post-doctoral grants SFRH/BD/19168/2004 (to S.L.) and SFRH/BPD/35005/2007 (to GAP.)). FEDER, the Grant Agency of the Czech Republic (grant no. 203/09/1056 (P.H.)), the Czech Academy of Sciences (grant no. KAN201110651 (P.H.)), the Ministry of Education, Youth and Sport of the Czech Republic (grant nos. MSM0021620857 (P.H.), LC06035 and ME09065 (PL.)), the Gabinete de Relacoes Internacionais da Ciencia e Ensino Superior (GRICES) of Portugal (Grices/AS CR 2006 (PH. and I.S.)) and the Institut National du Cancer and La Ligue Contre le Cancer, France (E.T.). The Varian VNMRS 600 NMR spectrometer in Coimbra was purchased with the support of the Programa Nacional de Reequipamento Cientifico of FCT, Portugal, contract REDE/1517/RMN/2005, as part of RNRMN (Rede Nacional de RMN). The authors thank to Dr. Ivana Cisarova for collection of the X-ray data of the ligand crystal and Radek Sevcik for technical assistance. This work was carried out within the framework of the COST D38 and BM607 Actions and EU-FP6

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