abstract
PDMS-SiO2 hybrid materials obtained by sol-gel process have been extensively studied over the past years due to its promising biomedical applications namely as bone substitutes, catheters, and drug delivery devices. Regardless of the intended biomedical application, all these materials should go through a sterilization process before interfacing with a living structure. However, it is unclear whether they undergo structural and microstructural changes when subjected to sterilization by gamma irradiation. This paper addresses this issue by showing that a sol-gel processed biomaterial based on the PDMS-CaO-SiO2 hybrid system suffers only small structural changes when submitted to a radiation dose of 25 kGy, the dose usually recommended to achieve a Sterility Assurance Level of 10(-6) when the natural contamination level and microorganism types cannot be calculated. The characterization was assessed by FT-IR, Si-29-{H-1} CP-MAS, thermal analysis (DTG), and SEM. (C) 2014 Elsevier B.V. All rights reserved.
keywords
MODIFIED CAO-SIO2-TIO2 HYBRIDS; NUCLEAR-MAGNETIC-RESONANCE; SI-29 NMR; IN-VITRO; FT-IR; SILOXANE; POLYDIMETHYLSILOXANE; NANOCOMPOSITES; HYDROLYSIS; TEOS
subject category
Materials Science
authors
Almeida, JC; Lancastre, J; Fernandes, MHV; Margaca, FMA; Ferreira, L; Salvado, IMM
our authors
Isabel Margarida Miranda Salvado
Associate Professor
José Carlos Martins de Almeida
Junior Researcher
Maria Helena Figueira Vaz Fernandes
Retired ProfessorGroups
G3 - Electrochemical Materials, Interfaces and Coatings
G5 - Biomimetic, Biological and Living Materials
acknowledgements
This work is financed by FEDER funds (Program COMPETE) and by FCT funds, on the project PTDC/CTM/101115/2008 and by the grants SFRH/BD/72074/2010 and RECI/AAG-TEC/0400/2012. We also acknowledge the program financing CICECO, Pest-C/CTM/LA0011/2013.