resumo
PDMS-SiO2 hybrid materials obtained by sol-gel process have been extensively studied over the past years due to its promising biomedical applications namely as bone substitutes, catheters, and drug delivery devices. Regardless of the intended biomedical application, all these materials should go through a sterilization process before interfacing with a living structure. However, it is unclear whether they undergo structural and microstructural changes when subjected to sterilization by gamma irradiation. This paper addresses this issue by showing that a sol-gel processed biomaterial based on the PDMS-CaO-SiO2 hybrid system suffers only small structural changes when submitted to a radiation dose of 25 kGy, the dose usually recommended to achieve a Sterility Assurance Level of 10(-6) when the natural contamination level and microorganism types cannot be calculated. The characterization was assessed by FT-IR, Si-29-{H-1} CP-MAS, thermal analysis (DTG), and SEM. (C) 2014 Elsevier B.V. All rights reserved.
palavras-chave
MODIFIED CAO-SIO2-TIO2 HYBRIDS; NUCLEAR-MAGNETIC-RESONANCE; SI-29 NMR; IN-VITRO; FT-IR; SILOXANE; POLYDIMETHYLSILOXANE; NANOCOMPOSITES; HYDROLYSIS; TEOS
categoria
Materials Science
autores
Almeida, JC; Lancastre, J; Fernandes, MHV; Margaca, FMA; Ferreira, L; Salvado, IMM
nossos autores
Grupos
G3 - Materiais Eletroquímicos, Interfaces e Revestimentos
G5 - Materiais Biomiméticos, Biológicos e Vivos
agradecimentos
This work is financed by FEDER funds (Program COMPETE) and by FCT funds, on the project PTDC/CTM/101115/2008 and by the grants SFRH/BD/72074/2010 and RECI/AAG-TEC/0400/2012. We also acknowledge the program financing CICECO, Pest-C/CTM/LA0011/2013.