authors |
Pinol, R; Brites, CDS; Bustamante, R; Martinez, A; Silva, NJO; Murillo, JL; Cases, R; Carrey, J; Estepa, C; Sosa, C; Palacio, F; Carlos, LD; Millan, A |
nationality |
International |
journal |
ACS NANO |
author keywords |
nanothermometers; nanoheaters; magnetic hyperthermia; intracellular temperature; heat diffusion |
keywords |
IRON-OXIDE NANOPARTICLES; MOLECULAR THERMOMETER; LIVING CELLS; TEMPERATURE; HYPERTHERMIA; NANOSCALE; FIELD |
abstract |
Whereas efficient and sensitive nanoheaters and nanothermometers are demanding tools, in modern bio- and nanomedicine, joining both features in a single nanoparticle still remains a real challenge, despite the recent progress achieved, Most Of it Within the last year. Here we demonstrate a successful realization of this challenge. The heating is magnetically induced, the temperature readout is optical, and the ratiometric thermometric probes are dual-emissive Eu3+/Tb3+ lanthanide complexes. The low thermometer heat capacitance (0.021 center dot K-1) and heater/thermometer resistance (1 K center dot W-1), the high temperature sensitivity (5.8%center dot K-1 at 296 K) and uncertainty (0.5 K), the physiological working temperature range (295-315 K), the readout reproducibility (>99.5%), and the fast time response (0.250 s) make the heater/thermometer nanoplatform proposed here unique. Cells were incubated with the nanoparticles, and fluorescence microscopy permits the mapping of the intracellular local temperature using the pixel-by-pixel ratio of the Eu3+/Tb3+ intensities. Time-resolved thermometry under an ac magnetic field evidences the failure of using Macroscopic thermal parameters to describe heat diffusion at the nanoscale. |
publisher |
AMER CHEMICAL SOC |
issn |
1936-0851 |
year published |
2015 |
volume |
9 |
issue |
3 |
beginning page |
3134 |
ending page |
3142 |
digital object identifier (doi) |
10.1021/acsnano.5b00059 |
web of science category |
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary |
subject category |
Chemistry; Science & Technology - Other Topics; Materials Science |
unique article identifier |
WOS:000351791800086
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ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
14.588 |
5 year journal impact factor |
15.211 |
category normalized journal impact factor percentile |
92.823 |
dimensions (citation analysis):
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altmetrics (social interaction):
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