resumo
A simple methodology giving access to the metal-free corroles of trans-A(2)B type, 5,15-bis (pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-(4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure. (C) 2015 Elsevier Inc. All rights reserved.
palavras-chave
HUMAN SERUM-ALBUMIN; FREE-BASE CORROLES; MESOSUBSTITUTED CORROLES; MANGANESE(III) CORROLE; PLATINUM COMPLEXES; FLUORESCENCE BEHAVIOR; NUCLEASE ACTIVITY; COUPLING REACTION; CHARGED CORROLES; IN-VITRO
categoria
Biochemistry & Molecular Biology; Chemistry
autores
Iglesias, BA; Barata, JFB; Pereira, PMR; Girao, H; Fernandes, R; Tome, JPC; Neves, MGPMS; Cavaleiro, JAS
nossos autores
Joana Filipa Brites Barata
Bolseiro de pós-DoutoramentoGrupos
agradecimentos
Thanks are due to FCT/MEC for the financial support to QOPNA research Unit (FCT UID/QUI/00062/2013), IBILI research Unit (FCT UID/NEU104539/2013) and CICECO-Aveiro Institute of Materials (FCT UID/CTM/50011/2013), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement, and also to the Portuguese NMR Network. Bernardo A. Iglesias acknowledges CNPq (Brazil) for his postdoc grant (Project No. 200802/2012-7 and No. 443625/2014-0) and BJT grant (Project No. 405588/2013-5), respectively. Joana F. B. Barata and Patricia M. R. Pereira also acknowledge FCT for their post-doctoral and doctoral research grants (SFRH/BPD/63237/2009) and (SFRH/BD/85941/2012), respectively.