resumo
This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photo-diagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
palavras-chave
THERAPY IN-VITRO; UP-CONVERSION NANOPARTICLES; SINGLET OXYGEN GENERATION; IRON-OXIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; PHOTOPHYSICAL PROPERTIES; BIOMEDICAL APPLICATIONS; COMBINED CHEMOTHERAPY; HYBRID NANOPARTICLES
categoria
Pharmacology & Pharmacy
autores
Borzecka, W; Trindade, T; Torres, T; Tome, J
nossos autores
Tito Trindade
Professor Catedrático
Wioleta Anna Borzecka
Estudante de doutoramentoagradecimentos
Thanks are due to FCT/MEC for the financial support to QOPNA (FCT UID/QUI/00062/2013), CICECO-Aveiro Institute of Materials (FCT UID/CTM/50011/2013) and CQE (FCT UID/QUI/0100/2013) research units, through national funds and where applicable cofinanced by the FEDER, within the PT2020 Partnership Agreement. The work was also supported by the Spanish MINECO (CTQ-2014-52869-P) and Comunidad de Madrid (FOTOCARBON, S2013/MIT-2841). We further wish to thank the Seventh Framework Programme (FP7-People-2012-ITN) for funding the SO2S project (grant agreement number: 316975).