Targeting Cancer Cells with Photoactive Silica Nanoparticles

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abstract

This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photo-diagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.

keywords

THERAPY IN-VITRO; UP-CONVERSION NANOPARTICLES; SINGLET OXYGEN GENERATION; IRON-OXIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; PHOTOPHYSICAL PROPERTIES; BIOMEDICAL APPLICATIONS; COMBINED CHEMOTHERAPY; HYBRID NANOPARTICLES

subject category

Pharmacology & Pharmacy

authors

Borzecka, W; Trindade, T; Torres, T; Tome, J

our authors

foto Tito Trindade

Tito Trindade

Full professor
foto Wioleta Anna Borzecka

Wioleta Anna Borzecka

PhD Student

Groups

G1 - Porous Materials and Nanosystems

Projects

CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)

SO2S - The Singlet Oxygen Strategy: sustainable oxidation procedures for applications in material science, synthesis, wastewater treatment, diagnostics and therapeutics (SO2S)

acknowledgements

Thanks are due to FCT/MEC for the financial support to QOPNA (FCT UID/QUI/00062/2013), CICECO-Aveiro Institute of Materials (FCT UID/CTM/50011/2013) and CQE (FCT UID/QUI/0100/2013) research units, through national funds and where applicable cofinanced by the FEDER, within the PT2020 Partnership Agreement. The work was also supported by the Spanish MINECO (CTQ-2014-52869-P) and Comunidad de Madrid (FOTOCARBON, S2013/MIT-2841). We further wish to thank the Seventh Framework Programme (FP7-People-2012-ITN) for funding the SO2S project (grant agreement number: 316975).

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Publication Details

type
Journal Article
year
2016
journal
CURRENT PHARMACEUTICAL DESIGN
volume
22
publisher
BENTHAM SCIENCE PUBL LTD
issn
1381-6128
issue
39
digital object identifier
10.2174/1381612822666160614083804
web of science article identifier
WOS:000390650400013

Journal Metrics (JCR 2019)

Journal Impact Factor
2.208
Journal Impact Factor (5 yrs)
2.575
category normalized journal percentile
33.889

Citations

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