resumo
The present study reports the development of non-cytotoxic and pH-sensitive nanostructured membranes consisting of a polymer with amino acid pending moieties and bacterial nanocellulose (BC). The nanocomposites were prepared through a simple methodology under green reaction conditions. The obtained materials display good thermal stability (up to 200 degrees C), viscoelastic (storage modulus > 700 MPa) and mechanical (Young's modulus =3.5-4.9 GPa) properties, together with high water uptake capacity. The results of the in vitro MTT assay showed that the nanocomposites are non-cytotoxic to HaCaT cells for 72 h. The in vitro release profile of diclofenac sodium salt (DCF) from the nanocomposites into simulated body fluids at different pH values demonstrates the pH-responsive behaviour of these materials. Besides, DCF is mainly retained in the nanocomposites at pH 2.1 and released at pH 7.4, revealing their potential for the controlled release of DCF in dermal as well as in oral drug delivery applications. (C) 2017 Elsevier Ltd. All rights reserved.
palavras-chave
BACTERIAL CELLULOSE MEMBRANES; DRUG-DELIVERY SYSTEMS; AMINO-ACID MOIETIES; BIOCELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; POLYMERIZATION; DISSOLUTION; NANOCOMPOSITES; METHACRYLATE; LIDOCAINE
categoria
Chemistry; Polymer Science
autores
Saidi, L; Vilela, C; Oliveira, H; Silvestre, AJD; Freire, CSR
nossos autores
Armando Jorge Domingues Silvestre
Professor Catedrático
Carla Vilela
Professor Auxiliar
Carmen Sofia da Rocha Freire Barros
Investigador Coordenador
Helena Oliveira
Bolseiro de pós-Doutoramento
Louise Saidi
Estudante de mestradoProjectos
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)
Functionalised Advanced Materials and Engineering of Hybrids and Ceramics - FAME (FAME)
agradecimentos
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. L. Saidi acknowledges the International Master Programme in Functionalized Advanced Materials & Engineering (FAME) funded by the Erasmus + Erasmus Mundus Programme of the European Union. The Portuguese Foundation for Science and Technology (FCT) is also acknowledged for the post-doctoral grants to C. Vilela (SFRH/BPD/84168/2012) and H. Oliveira (SFRH/BPD/111736/2015), and a contract under Investigador FCT to C.S.R. Freire (IF/01407/2012).