Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity


In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.




Materials Science


Capela, MN; Tobaldi, DM; Oliveira, C; Pereira, A; Duarte, AS; Seabra, MP; Fernandes, MHV

nossos autores


The authors acknowledge the financial support from CENTRO-07-0924-FEDER-002030 "Biomaterials for Regenerative Medicine" and the project CICECO-Aveiro Institute of Materials (Ref. FCT UID/CTM /50011/2013), financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. The authors acknowledge Dr. M.J. Ribeiro (Polytechnic Institute of Viana do Castelo, ESTG, Viana Do Castelo, Portugal) for the assistance in the thermal analysis. C. Oliveira was supported through grant SFRH/BPD/65820/2009 from Fundo Social Europeu and by Ministerio da Ciencia, Tecnologia e Ensino Superior, Portugal.

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