abstract
In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.
keywords
BOROSILICATE GLASSES; DISSOLUTION; BACTERIA
subject category
Materials Science
authors
Capela, MN; Tobaldi, DM; Oliveira, C; Pereira, A; Duarte, AS; Seabra, MP; Fernandes, MHV
our authors
David Maria Tobaldi
Researcher
Maria Helena Figueira Vaz Fernandes
Retired Professor
Maria Paula Seabra
Assistant Professor
Marinélia Capela
ResearcherGroups
G4 - Renewable Materials and Circular Economy
G5 - Biomimetic, Biological and Living Materials
acknowledgements
The authors acknowledge the financial support from CENTRO-07-0924-FEDER-002030 "Biomaterials for Regenerative Medicine" and the project CICECO-Aveiro Institute of Materials (Ref. FCT UID/CTM /50011/2013), financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. The authors acknowledge Dr. M.J. Ribeiro (Polytechnic Institute of Viana do Castelo, ESTG, Viana Do Castelo, Portugal) for the assistance in the thermal analysis. C. Oliveira was supported through grant SFRH/BPD/65820/2009 from Fundo Social Europeu and by Ministerio da Ciencia, Tecnologia e Ensino Superior, Portugal.