authors |
Carvalho, JPF; Silva, ACQ; Bastos, V; Oliveira, H; Pinto, RJB; Silvestre, AJD; Vilela, C; Freire, CSR |
nationality |
International |
journal |
NANOMATERIALS |
author keywords |
bacterial nanocellulose; hyaluronic acid; diclofenac; nanostructured patches; drug delivery; aphthous stomatitis |
keywords |
BACTERIAL CELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; PHYSICAL-PROPERTIES; TOPICAL DICLOFENAC; CONTROLLED-RELEASE; COMPOSITES; DISSOLUTION; EFFICACY; SYSTEMS; GROWTH |
abstract |
Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 degrees C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis. |
publisher |
MDPI |
isbn |
2079-4991 |
year published |
2020 |
volume |
10 |
issue |
4 |
digital object identifier (doi) |
10.3390/nano10040628 |
web of science category |
Nanoscience & Nanotechnology; Materials Science, Multidisciplinary |
subject category |
Science & Technology - Other Topics; Materials Science |
unique article identifier |
WOS:000539577200031
|