Polystyrene nanoplastics alter the cytotoxicity of human pharmaceuticals on marine fish cell lines
authors Almeida, M; Martins, MA; Soares, AMV; Cuesta, A; Oliveira, M
nationality International
journal ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
author keywords Polystyrene; In vitro; Human pharmaceuticals; Combined exposures
keywords OXIDATIVE STRESS; MICROPLASTIC INGESTION; SILICA NANOPARTICLES; HEAD-KIDNEY; ORGANISMS; TOXICITY; AURATA; GEMFIBROZIL; ADSORPTION; TRANSPORT
abstract There is an increasing concern on the consequences of the presence of micro(nano)plastics to marine organisms. The present study aimed to provide information on the effects of polystyrene nanoplastics (PSNPs) to fish cells alone and combined with human pharmaceuticals, other emerging contaminants, using as biological models marine fish cell lines SAF-1 and DLB-1. Cells were exposed for 24 h to 100 tun PSNPs, starting at 0.001 up to 10 mg/L, to assess effects on viability and activity of catalase (antioxidant defense) and glutathione S-trans-ferases (phase II biotransformation and antioxidant defense). The viability of cells was also evaluated after exposure to human pharmaceuticals alone and combined with PSNPs. Overall, PSNPs failed to be cytotoxic but data proved their ability to alter the toxicity of human pharmaceuticals. DLB-1 was the most sensitive cell line to PSNPs. Data support the use of marine fish cell lines in the study of the effects of micro(nano)plastics.
publisher ELSEVIER SCIENCE BV
issn 1382-6689
isbn 1872-7077
year published 2019
volume 69
beginning page 57
ending page 65
digital object identifier (doi) 10.1016/j.etap.2019.03.019
web of science category Environmental Sciences; Pharmacology & Pharmacy; Toxicology
subject category Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
unique article identifier WOS:000472813600008
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.292
5 year journal impact factor 3.162
category normalized journal impact factor percentile 66.634
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg