An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination

resumo

Herein, we have reported a low cost simple aminoquinoline based pH sensor HL [HL = 2-methoxy-6-((quinolin-3-ylimino)methyl)phenol]. HL acts as a potential low pH fluorometric as well as colourimetric pH probe. In acidic media it is colourless whereas, in basic media, it is yellow in colour. HL is thoroughly characterized by different spectroscopic techniques viz. UV-visible, fluorescence, H-1 and C-13 NMR spectroscopy along with ESI-MS and elemental analysis. We are successful in elucidating the X-ray crystal structure of HL. Theoretical calculations such as DFT and TDDFT are also performed to support our experimental findings. The ability of this biocompatible pH sensor (HL) to differentiate normal and cancer cells by alteration of pH will open new vistas for various biomedical applications.

palavras-chave

DENSITY-FUNCTIONAL THEORY; EFFECTIVE CORE POTENTIALS; COLORIMETRIC CHEMOSENSOR; MOLECULAR CALCULATIONS; EXCITATION-ENERGIES; CRYSTAL-STRUCTURES; INTRACELLULAR PH; COMPLEXES; PROBE; APPROXIMATION

categoria

Chemistry

autores

Mandal, J; Ghorai, P; Brandao, P; Pal, K; Karmakar, P; Saha, A

nossos autores

agradecimentos

A. S. gratefully acknowledges the financial support of this work by the DST, India (Sanction No. SB/FT/CS-102/2014, dated-18.07.2015). A. S. sincerely acknowledges Dr Partha Roy, Associate Professor, Department of Chemistry, Jadavpur University for scientific help.

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