An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination
authors Mandal, J; Ghorai, P; Brandao, P; Pal, K; Karmakar, P; Saha, A
nationality International
journal NEW JOURNAL OF CHEMISTRY
keywords DENSITY-FUNCTIONAL THEORY; EFFECTIVE CORE POTENTIALS; COLORIMETRIC CHEMOSENSOR; MOLECULAR CALCULATIONS; EXCITATION-ENERGIES; CRYSTAL-STRUCTURES; INTRACELLULAR PH; COMPLEXES; PROBE; APPROXIMATION
abstract Herein, we have reported a low cost simple aminoquinoline based pH sensor HL [HL = 2-methoxy-6-((quinolin-3-ylimino)methyl)phenol]. HL acts as a potential low pH fluorometric as well as colourimetric pH probe. In acidic media it is colourless whereas, in basic media, it is yellow in colour. HL is thoroughly characterized by different spectroscopic techniques viz. UV-visible, fluorescence, H-1 and C-13 NMR spectroscopy along with ESI-MS and elemental analysis. We are successful in elucidating the X-ray crystal structure of HL. Theoretical calculations such as DFT and TDDFT are also performed to support our experimental findings. The ability of this biocompatible pH sensor (HL) to differentiate normal and cancer cells by alteration of pH will open new vistas for various biomedical applications.
publisher ROYAL SOC CHEMISTRY
issn 1144-0546
year published 2018
volume 42
issue 24
beginning page 19818
ending page 19826
digital object identifier (doi) 10.1039/c8nj04753g
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000456501100059
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journal impact factor 3.288
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