Copper(II) and cobalt(II) complexes of 5-methyl pyrazole-3-carboxylic acid: synthesis, X-ray crystallography, thermal analysis and in vitro antimicrobial activity
authors Santra, A; Brandao, P; Jana, H; Mondal, G; Bera, P; Jana, A; Bera, P
nationality International
journal JOURNAL OF COORDINATION CHEMISTRY
author keywords Pyrazolyl; inner-metallic; thermogravimetry; antibacterial-antifungal; mono/polymeric
keywords PYRAZOLE DERIVATIVES; ANTIFUNGAL ACTIVITY; CRYSTAL-STRUCTURE; CU(II) COMPLEXES; ANTIBACTERIAL; DNA; CHEMISTRY; LIGANDS; BINDING; CU
abstract The coordination behavior of 5-methylpyrazole-3-carboxylic acid (Hmpca) has been demonstrated by the solid state isolation and characterization of [Cu(mpca)(2)(H2O)]center dot 3H(2)O (1) [Cu(mpca)(2)]center dot H2O (2) and [Co(mpca)(2)(H2O)(2)] (3). The new compounds are characterized by X-ray crystallography, thermogravimetric analysis and DFT study. The redox properties of the complexes are examined by cyclic voltammetric analysis. The antibacterial and antifungal activities of the compounds against eight bacteria (Escherichia coli, Enterococcus faecalis, Bacillus subtilis, Klebsiella pneumoniae, Proteus vulgaris, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi) and two fungi (Aspergillus flavus and Candida albicans) are screened using modified agar well diffusion method. The metal complexes demonstrate better inhibition on all bacteria and fungi than the ligand. The high lipophilicity of the complexes accounts for good inhibitory action toward microbes. Among the reported complexes, 3 emerges as an excellent antifungal agent and a better antibiotic than standard fluconazole. The structure and activity relationship indicate that complexes having sufficient Jahn-Teller distortion with high logP values, cross the cell membrane of the microbes creating intercellular damage.
publisher TAYLOR & FRANCIS LTD
issn 0095-8972
year published 2018
volume 71
issue 22
beginning page 3648
ending page 3664
digital object identifier (doi) 10.1080/00958972.2018.1520984
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000461425800003
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journal analysis (jcr 2019):
journal impact factor 1.41
5 year journal impact factor 1.269
category normalized journal impact factor percentile 34.444
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