Multifunctionality and cytotoxicity of a layered coordination polymer


This work reports the synthesis and multifunctionality of 2D layered coordination polymers formulated as [Ln(2)(H(3)nmp)(2)]xH(2)O (1, where Ln = Sm3+, Eu3+, Tb3+, Dy3+, Ho3+, Er3+ and Y3+) (x = 1 to 4). We describe detailed synthesis of the materials using various methods [typical hydrothermal reaction (HT), microwave-assisted synthesis (MWAS) and one-pot method (OP)], while discussing the various crystal morphologies which can be fine tuned by varying systematically the conditions. We further explore the multifunctionality of this material by studying its heterogeneous catalytic activity in the ring opening of styrene oxide, its photoluminescence behaviour and its cytotoxicity. A conversion of 88%/100% yield at 4 h/24 h reaction respectively, with excellent selectivity towards 2-methoxy-2-phenylethanol product (100%) was observed. Photoluminescence properties of the optically-active [Eu-2(H(3)nmp)(2)]xH(2)O (1Eu) and the mixed-lanthanide [(Gd0.95Eu0.5)(2)(H(3)nmp)(2)]xH(2)O (1GdEu), on the other hand, show potential use for UV-to-visible light converters, with lifetimes of 2.31 +/- 0.01 and 2.61 +/- 0.01 ms at ambient temperature for 1Eu and 1GdEu samples. Preliminary cytotoxic studies showed no effects on metabolic activity of both in vitro human epithelial kidney (HK-2) and human hepatocellular carcinoma (HepG2) cell lines. A reduction of NR uptake was, however, observed indicating some cytotoxic effect on lysosomal activity.






Silva, P; Mendes, RF; Fernandes, C; Gomes, AC; Ananias, D; Remiao, F; Borges, F; Valente, AA; Paz, FAA

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This work was developed within the scope of the project CICECO - Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. The work was also supported by UID/MULTI/04378/2019 and UID/QUI/00081 with funding from FCT/MCTES through national funds. CF grant is supported by FCT, POPH and FEDER/COMPETE. FCT is also gratefully acknowledged for the Junior Research Position CEECIND/00553/2017 (to RFM), for the Assistant Research Position CEECIND/02128/2017 (to ACG) and for the doctoral research grant No. SFRH/BD/46601/2008 (to PS).

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