Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review

authors	Evtyugin, DD; Magina, S; Evtuguin, DV
nationality	International
journal	MOLECULES
author keywords	ellagic acid; ellagitannins; urolithins; antioxidant properties; biological activity; bioavailability; production routes
keywords	ENHANCING ORAL BIOAVAILABILITY; RADICAL SCAVENGING ACTIVITY; CASTANEA-SATIVA MILL.; DRUG-DELIVERY-SYSTEM; ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; ASPERGILLUS-NIGER; GALLIC ACID; EUCALYPTUS-GRANDIS; ROXBIN B
abstract	Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA). They are mostly found as a part of extractives in angiosperms. As known antioxidants and chelators, EA and EA derivatives are drawing an increasing interest towards extensive technical and biomedical applications. The latter ones include possible antibacterial, antifungal, antiviral, anti-inflammatory, hepato- and cardioprotective, chemopreventive, neuroprotective, anti-diabetic, gastroprotective, antihyperlipidemic, and antidepressant-like activities, among others. EA's synthesis and production challenges prompt further research on new methods and alternative sources. Conventional and prospective methods and raw materials for the production of EA and its derivatives are reviewed. Among the potential sources of EA, the residues and industrial streams of the pulp industry have been highlighted and considered as an alluring alternative in terms of commercial exploitation.
publisher	MDPI
isbn	1420-3049
year published	2020
volume	25
issue	12
digital object identifier (doi)	10.3390/molecules25122745
web of science category	Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category	Biochemistry & Molecular Biology; Chemistry
unique article identifier	WOS:000553979500001