abstract
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA). They are mostly found as a part of extractives in angiosperms. As known antioxidants and chelators, EA and EA derivatives are drawing an increasing interest towards extensive technical and biomedical applications. The latter ones include possible antibacterial, antifungal, antiviral, anti-inflammatory, hepato- and cardioprotective, chemopreventive, neuroprotective, anti-diabetic, gastroprotective, antihyperlipidemic, and antidepressant-like activities, among others. EA's synthesis and production challenges prompt further research on new methods and alternative sources. Conventional and prospective methods and raw materials for the production of EA and its derivatives are reviewed. Among the potential sources of EA, the residues and industrial streams of the pulp industry have been highlighted and considered as an alluring alternative in terms of commercial exploitation.
keywords
ENHANCING ORAL BIOAVAILABILITY; RADICAL SCAVENGING ACTIVITY; CASTANEA-SATIVA MILL.; DRUG-DELIVERY-SYSTEM; ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; ASPERGILLUS-NIGER; GALLIC ACID; EUCALYPTUS-GRANDIS; ROXBIN B
subject category
Biochemistry & Molecular Biology; Chemistry
authors
Evtyugin, DD; Magina, S; Evtuguin, DV
our authors
Dmitry Dmitrievitch Evtyugin
Collaborator
Dmitry Evtyugin
Associate Professor with Aggregation
Sandra Pereira Magina
Researcheracknowledgements
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 and UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. The authors acknowledge Fundacao para a Ciencia e Tecnologia (FCT) for PhD grant SFRH/BD/121275/2016. The financial support from Caima-Industria de Celulose SA is greatly acknowledged.