Bisphosphonates, Old Friends of Bones and New Trends in Clinics
authors Barbosa, JS; Paz, FAA; Braga, SS
nationality International
journal JOURNAL OF MEDICINAL CHEMISTRY
keywords IN-VITRO EVALUATION; 1-PERCENT ALENDRONATE GEL; LOCAL-DRUG DELIVERY; NITROGEN-CONTAINING BISPHOSPHONATES; HIV-1 REVERSE-TRANSCRIPTASE; RHEUMATOID-ARTHRITIS; ZOLEDRONIC ACID; MEVALONATE PATHWAY; INTRAVENOUS BISPHOSPHONATE; OSTEOGENESIS IMPERFECTA
abstract Bisphosphonates, used for a long time in osteoporosis management, are currently the target of intensive research, from pre-formulation studies to more advanced stages of clinical practice. This review presents an overview of the contributions of this family of compounds to human health, starting with the chemistry and clinical uses of bisphosphonates. Following this, their pharmacology is described, highlighting administration-borne handicaps and undesirable effects. The last three sections of the review describe the research efforts that seek to curb delivery-related issues and expand bisphosphonate use. Innovative routes and strategies of administration, such as nano-encapsulation for oral intake or injectable cements for local or in-bone delivery are presented, as well as the latest results of case studies or preclinical studies proposing new therapeutic indications for the clinically approved bisphosphonates. Finally, a selection of anti-infectious bisphosphonate new drug candidates is shown, with focus on the molecules reported in the last two decades.
publisher AMER CHEMICAL SOC
issn 0022-2623
isbn 1520-4804
year published 2021
volume 64
issue 3
beginning page 1260
ending page 1282
digital object identifier (doi) 10.1021/acs.jmedchem.0c01292
web of science category 23
subject category Chemistry, Medicinal
unique article identifier WOS:000619743200002
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 6.205
5 year journal impact factor 6.521
category normalized journal impact factor percentile 95.902
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