resumo
The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics. The first section describes the most commonly studied application of cyclodextrins-solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity. The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents. In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently under development. Lastly, the use of cyclodextrins as pharmaceutical active ingredients for the treatment of viral infections is explored. This new field of application is still taking its first steps. Nevertheless, promising results from the use of cyclodextrins as agents to treat other pathologies are encouraging. We present potential applications of the results reported in the literature and highlight the products that are already available on the market.
palavras-chave
HYDROXYPROPYL-BETA-CYCLODEXTRIN; SIMIAN IMMUNODEFICIENCY VIRUS; INFLUENZA-A VIRUS; SQUALANE-IN-WATER; SULFOLIPO-CYCLODEXTRIN; CHOLESTEROL DEPLETION; ORAL BIOAVAILABILITY; VAGINAL TRANSMISSION; SAQUINAVIR MESYLATE; INCLUSION COMPLEX
categoria
Pharmacology & Pharmacy
autores
Braga, SS; Barbosa, JS; Santos, NE; El-Saleh, F; Paz, FAA
nossos autores
Filipe Alexandre Almeida Paz
Investigador Principal
Jéssica Barbosa
Estudante de doutoramento
Susana Isabel Fonseca de Almeida Santos Braga
Investigadoragradecimentos
We acknowledge University of Aveiro and FCT/MCTES (Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, da Tecnologia e do Ensino Superior) for financial support to LAQVREQUIMTE (Ref. UIDB/50006/2020) and CICECO-Aveiro Institute of Materials (UIDB/50011/2020 and UIDP/50011/2020). We also thank FCT for the Ph.D. grant No. PD/BD/135104/2017 to J.S.B.