Cyclodextrins in Antiviral Therapeutics and Vaccines
authors Braga, SS; Barbosa, JS; Santos, NE; El-Saleh, F; Paz, FAA
nationality International
journal PHARMACEUTICS
author keywords antiviral drugs; inclusion complexes; cyclodextrins; vaccines
keywords HYDROXYPROPYL-BETA-CYCLODEXTRIN; SIMIAN IMMUNODEFICIENCY VIRUS; INFLUENZA-A VIRUS; SQUALANE-IN-WATER; SULFOLIPO-CYCLODEXTRIN; CHOLESTEROL DEPLETION; ORAL BIOAVAILABILITY; VAGINAL TRANSMISSION; SAQUINAVIR MESYLATE; INCLUSION COMPLEX
abstract The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics. The first section describes the most commonly studied application of cyclodextrins-solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity. The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents. In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently under development. Lastly, the use of cyclodextrins as pharmaceutical active ingredients for the treatment of viral infections is explored. This new field of application is still taking its first steps. Nevertheless, promising results from the use of cyclodextrins as agents to treat other pathologies are encouraging. We present potential applications of the results reported in the literature and highlight the products that are already available on the market.
publisher MDPI
isbn 1999-4923
year published 2021
volume 13
issue 3
digital object identifier (doi) 10.3390/pharmaceutics13030409
web of science category 24
subject category Pharmacology & Pharmacy
unique article identifier WOS:000634093500001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.421
5 year journal impact factor Not Available
category normalized journal impact factor percentile 83.889
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