NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments
authors Ariana C. F. Santos, Luís P. G. Monteiro, Adriana C. C. Gomes, Fátima Martel, Teresa M. Santos, Bárbara J. M. Leite Ferreira
nationality International
journal International Journal of Molecular Sciences
abstract After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs’ biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs’ properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
year published 2022
volume 23
issue 5
beginning page 2855
link https://doi.org/10.3390/ijms23052855
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journal analysis (jcr 2019):
journal impact factor 4.556
5 year journal impact factor 4.653
category normalized journal impact factor percentile 74.208
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