resumo
After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs' biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs' properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
palavras-chave
NONSTEROIDAL ANTIINFLAMMATORY DRUG; TOLFENAMIC ACID STRUCTURE; METAL-COMPLEXES; IN-VITRO; ANTIOXIDANT ACTIVITY; BIOLOGICAL EVALUATION; COBALT(II) COMPLEXES; DNA-INTERACTION; ZINC-COMPLEXES; STRUCTURAL-CHARACTERIZATION
categoria
Biochemistry & Molecular Biology; Chemistry
autores
Santos, ACF; Monteiro, LPG; Gomes, ACC; Martel, F; Santos, TM; Ferreira, BJML
nossos autores
Adriana Gomes
Estudante de doutoramento
Ariana Santos
Estudante de doutoramento
Bárbara Joana Martins Leite Ferreira
Investigador Júnior
Luís Pedro Gomes Monteiro
Estudante de doutoramento
Teresa Margarida dos Santos
Professor(a) Jubilado(a)Projectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 and LA/P/0006/2020, financed by national funds through the FCT/MEC (PIDDAC). A.S. gratefully acknowledges FCT for her doctoral grant (2021.08157.BD) The position held by B.J.M.L.F.was finanted by national funds (OE), through FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5 and 6 of Article 23, of the Decree-Law 57/2006, of August 29, changed by Law 57/19 July 2017.