resumo
In the past years, large efforts have been placed in the development of novel separation techniques with improved resolution, simplicity, speed and easy to scale-up. Among these, ionic-liquid-based (IL-based) aqueous biphasic systems (ABS) have been broadly proposed for the separation of high-value compounds, allowing improved extraction performance and purification. More recently, significant efforts have been arranged on the synthesis and use of novel ILs with both an acceptable environmental footprint and enhanced biocompatibility. In this sense, this work aims to characterize ABS composed of cholinium carboxylate ILs ([Ch][CnO2], with n = 2 to 7), K3PO4 and water. The respective ternary phase diagrams, including binodal curves, tie-lines and tie-line lengths, were determined at (298 +/- 1) K and at atmospheric pressure. The ability to form ABS (or of the IL to be salted-out) increases with the increase of the alkyl chain length of the IL anion, up to [Ch][C5O2]; nevertheless, for longer anion alkyl chain lengths ([Ch][C6O2] and [Ch][C7O2]) the ILs self-aggregation leads to a decrease of the ILs ability to form ABS. The liquid-liquid equilibrium data experimentally determined were modeled using the local composition activity coefficient model NRTL (Non-Random Two Liquid). Finally, the partition behavior of three alkaloids (nicotine, caffeine and theobromine), used here as hydrophobicity probes, was evaluated. In all studied systems, alkaloids preferentially migrate to the IL-rich phase, with partition coefficients (K) ranging between 2.23 and complete extraction, in a single-step. Furthermore, the set of ILs investigated allowed identifying an odd-even effect in the alkaloids partitioning derived from the IL anion alkyl chain length. These results support the salting-out effect exerted by K3PO4 and favorable dispersive interactions established between the IL-rich phase-forming components and the alkaloids. (C) 2022 Elsevier B.V. All rights reserved.
palavras-chave
IONIC LIQUIDS; 2-PHASE SYSTEMS; EXTRACTION PERFORMANCE; HYDROPHOBICITY; ALKALOIDS; EFFICIENT
categoria
Thermodynamics; Chemistry; Engineering
autores
Almeida, MR; Rufino, AFCS; Belchior, DCV; Carvalho, PJ; Freire, MG
nossos autores
Ana Filipa Correia Santos Rufino
Estudante de doutoramento
Ana Mafalda Rodrigues Almeida Rocha
Investigador
Diana Cléssia Vieira Belchior
Estudante de doutoramento
Mara Guadalupe Freire Martins
Investigador Coordenador
Pedro J. Carvalho
Professor AuxiliarGrupos
G4 - Materiais Renováveis e Economia Circular
G5 - Materiais Biomiméticos, Biológicos e Vivos
agradecimentos
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0 0 06/2020, financed by national funds through the FCT/MEC (PIDDAC). This research was funded by FEDER through COMPETE 2020-Programa Operacional Competitividade e Internacionalizacao (POCI), and by national funds (OE), through FCT/MCTES from the project IL2BioPro-PTDC/BII-BBF/30840/2017. A.F.C.S. Rufino acknowledges FCT for the PhD grant SFRH/BD/138997/2018.