resumo
Three-dimensional printing has risen in recent years as a promising approach that fast-tracked the biofabrication of tissue engineering constructs that most resemble utopian tissue/organ replacements for precision medicine. Additionally, by using human-sourced biomaterials engineered towards optimal rheological proprieties of extrudable inks, the best possible scaffolds can be created. These can encompass native structure and function with a low risk of rejection, enhancing overall clinical outcomes; and even be further optimized by engaging in information- and computer-driven design workflows. This paper provides an overview of the current efforts in achieving ink's necessary rheological and print performance proprieties towards biofabrication from human-derived biomaterials. The most notable step for arranging such characteristics to make biomaterials inks are the employed crosslinking strategies, for which examples are discussed. Lastly, this paper illuminates the state-of-the-art of the most recent literature on already used human-sourced inks; with a final emphasis on future perspectives on the field.
palavras-chave
GELATIN-METHACRYLOYL HYDROGELS; EXTRACELLULAR-MATRIX; MECHANICAL-PROPERTIES; CROSS-LINKING; TISSUE CONSTRUCTS; STRESS-RELAXATION; SHEAR-STRESS; STEM-CELLS; COLLAGEN; BIOFABRICATION
categoria
Materials Science
autores
Maia, JR; Sobreiro-Almeida, R; Cleymand, F; Mano, JF
nossos autores
João Mano
Vice-Diretor
Rita Sobreiro Almeida
Investigador JúniorProjectos
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
The authors wish to acknowledge the support of European Union (EU) Horizon 2020 for the project InterLynk (Grant agreement: H2020-NMBP-TR-IND-2020, project ID: 953169), the European Research Council for the project REBORN (ERC-2019-ADG-883370) and also FCT for the projects CIRCUS (PTDC/BTM-MAT/31064/2017) and COP2P (PTDC/QUI-QOR/30771/2017, POCI-01-0145-FEDER-030771) when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. It was also developed within the scope of the project CICECO-Aveiro Institute of Materials, (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020). This work was also supported by the French PIA project 'Lorraine Universite d'excellence', reference ANR-15-IDEX-04-LUE and within the scope of the UL-International Research Project (French-Portuguese) HOPE and also, within the framework of the Canceropole GE project and supported by the Chaire Gutenberg of JFM (2020).