Shaping Cytotoxicity of Organometallics and Complex Antitumorals via Molecular Encapsulation

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abstract

This chapter deals with the effects of molecular encapsulation on the improvement of solubility and cytotoxic action of organometallic and metal coordination complexes. Described results will focus on our group’s research on the effects of nanoencapsulation with cyclodextrins, complemented with relevant work from the literature.Most of the encapsulated guests herein presented are known antitumorals. Considering the broader range of action of metal cytotoxic compounds, the advantages of encapsulation of some biocidal compounds will also be presented.The chapter is divided into three subsections according to the kind of molecular capsules typically employed. Section one will deal with the use of cyclodextrins, sugar rings that help camouflaging the metal guests thus rendering them more soluble, selective, biocompatible and less toxic. The following two sections summarize relevant literature results on the encapsulation of metal antitumorals with calixarenes and cucurbiturils. Finally, a small section presents the most recent results on custom-designed molecular capsules to obtain specificity towards neoplasic cell targets.

authors

Paz F A A, Braga SS

our authors

foto Filipe Alexandre Almeida Paz

Filipe Alexandre Almeida Paz

Principal Researcher
foto Susana Isabel Fonseca de Almeida Santos Braga

Susana Isabel Fonseca de Almeida Santos Braga

Researcher

Groups

G1 - Porous Materials and Nanosystems

Other

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Publication Details

type
Book Chapter
year
2010
Book Title
Organometallic Compounds: Preparation, Structure and Properties
editors
H. F. Chin, Hauppauge
publisher
Nova Science Publishers
isbn
978-1-60741-917-4

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