Animal Protein-based Soft Materials for Tissue Engineering Applications

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abstract

Proteins have long been used in coatings for cell culture plates and to supplement cell culture media. Due to their unmatched biocompatibility, biodegradability, bioactivity and immune-privilege, the interest in proteins rapidly advanced for the design and engineering of more complex substrates for biomedical applications. In this chapter, the proteins typically used in the design and fabrication of biomedical devices are presented and discussed, with particular focus in human-based platforms. However, restrictions in the use of protein-derived materials are associated with their limited processability and stability, but to overcome this, multiple bioconjugation techniques have been described and are herein presented. An overview of current protein-based materials that have found clinical application and that have been commercialized is also provided.

authors

C. A. Custódio, S. C. Santos, C. F. Monteiro, I. A. Deus, M. C. Gomes, J. F. Mano

our authors

foto Catarina de Almeida Custódio

Catarina de Almeida Custódio

Assistant Researcher
foto Cátia Filipa Rodrigues Monteiro

Cátia Filipa Rodrigues Monteiro

Junior Researcher
foto João Mano

João Mano

Vice Director

Groups

G5 - Biomimetic, Biological and Living Materials

Other

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Publication Details

type
Book Chapter
year
2021
Book Title
Soft Matter for Biomedical Applications
editors
Helena S. Azevedo, João F. Mano, João Borges
publisher
Royal Society of Chemistry
isbn
978-1-78801-757-2
book digital object identifier
10.1039/9781839161124-00660

Citations

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