Maria de Fátima Pereira Duarte

Investigador Principal

Perfil biográfico

Interesses científicos

Grupo de Investigação

14- "RefinOlea: Valorização integrada de resíduos e subprodutos da extracção de azeite" a project in ADI Co-promotion (ref. FCOMP-01-0202-FEDER-005450), as part of the research team, CEBAL Coordinator June 2009.

15- "Antiangiogenic potential of Cynara cardunculus extracts in Hepatocellular Carcinoma therapy", Coordinator September 2009.

16- "Removal of cytotoxic chemotherapy compounds from pharmaceutical/hospital wastewaters by combined membrane processing and advanced electro-oxidation treatment" as participant institution (FCT reference:PTDC/AAC-AMB/100960/2008), January 2010.

17- "Anti-angiogenic potential of Cynara cardunculus leaves extracts on human breast cancer cells", ref. CBL/LFD/RP07/2010, Coordinator September 2010.

18- "BIECOS: Valorização Integrada de Biomassa", a QREN project, as member of the research team, Octocber 2010.

19- "Biological characterization of E. grandis x globulus bark lipophilic extractives on human breast cancer cell lines", as part of the European Project AFORE (FP7) coordinated by VTT, as part of the CICECO´s research team, November 2010.

20- "AFORE: Forest biorefineries: Added-value from chemicals and polymers by new integrated separation, fractionation and upgrading technologies", 2009-2013, FP7-NMP-2008-LARGE-2, as part as the research team of WP3, since November 2010

21 - RitecaII - Research network Portugal-Spain - including Extremadura, Centro e Alentejo (Phase II), as part of the research team, CEBAL Coordinator January 2011.

22- "NEW PROTECTION: NativE, Wild PRObiotics sTrain EffeCT in Olives in briNe" as participant institution (FCT reference: PTDC/AGR-ALI/117658/2010), Novembro 2011.

23- "Desenvolvimento da fileira da romã – Da planta ao bago pronto a comer", ref. ProDeR 45071, as part of the research team, June 2013.

24- "NEucBark – new valorization strategies for Eucalyptus spp. bark extracts" as responsible investigator (FCT reference: : PTDC/AGR-FOR/3187/2012), June 2013.

Principais colaboradores


Actividade pedagógica

Publicações seleccionadas

Schmitt, F.C., Reis-Filho, J.S., Milanezi, F., Soares, R., Duarte, F., Seixas, C. and Cameselle-Teijeiro, J.F. Pathology of hereditary breast cancer. Revista de Senologia y Patología Mamaria, 2001; 14:29-35.

Duarte, F., Cameselle-Teijeiro, J.F., Soares, R., Seixas, C., Cortizo-Torres, M.E. and Schmitt, F.C., Analysis of mutations in genes BRCA1 and BRCA2 among patients with breast and ovarian cancer in northern Portugal and Galicia. Rev. Clinica. Española, 2002, 202:259-263.

Cortizo-Torres, M.E., Duarte, F., Schmitt, F.C., Cameselle-Teijeiro, J.F. and Lopez-Touza, A., Criteria for definition of hereditary breast cancer in a clinic perspective. The Breast Journal, 2002; 8:402-403.

Cortizo-Torres, M.E., Cameselle-Teijeiro, J.F., López-Touza, A., Duarte, F. and Schmitt, F.C., Chronobiology and Breast Cancer. The Breast Journal, 2003; 9:453-454.

Prudovksy, I., Mandinova, A., Soldi, R., Bagalá, C., Graziani, I., Landriscina, M., Tarantini, F., Duarte, M., Bellum, S., Doherty, H. and Maciag, T. The non-classical export routes: IL1 alpha; and FGF1 and IL1 alpha; point the way. Journal of Cell Science, 2003; 116 (24):4871-4881.

Kolev, K., Kacer, D., Trifonova, R., Small, D., Duarte, M., Soldi, R., Graziani, I., Sideleva, O., Larman, B., Maciag, T. and Prudovsky, I. The intracellular domain of Notch ligand Delta1 induces cell growth arrest. FEBS Lettters 2005; 579:5798-5802.

Graziani, I., Bagalá, C., Duarte, M., Soldi, R., Kolev, K., Tarantini, F., Kumar, T.K.S., Doyle, A., Neivandt, D., Yu, C., Maciag, T., and Prudovsky, I. Release of FGF1 and p40 Synaptotagnin 1 correlates with their membrane destabilizing ability. Biochemical and Biophysical Research Communications, 2006; Oct 13; 349(1):192-198.

Duarte M., Kolev, V., Soldi, R., Kirov, A., Graziani, I., Oliveira, S.M., Kacer, D., Friesel, R., Maciag, T., and Prudovsky, I. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochemical and Biophysical Research Communications, 2006; Nov 24; 350(3):604-9.

Di Serio, C., Pellerito, S., Duarte, M., Massi, D., Naldini, A., Micucci, I., Doria, L., Mirone, P., Cirino, G., Prudovsky, I., Santucci, M., Geppetti, P., Masotti, G., and Tarantini, F. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic & Clinical Pharmacology & Toxicology 2007; 101(1):63-69.

Duarte, M., Longatto Filho, A. and Schmitt, F.C. Angiogenesis, haemostasis and cancer: new paradigms old concerns. Journal Brasileiro de Patologia Médica Laboratorial, Review Paper. 2007; 43(6):441-449.

Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M.A., Pitson, S.M., Duarte, M., Graziani, I., Kolev, K., Kacer, D., Kirov, A., Maciag, T., and Prudovsky, I. Sphingosine Kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research 2007; 313(15):3308-3318.

Nikopoulos, G.N., Duarte, M., Kubu, C.J., Bellum, S., Friesel, R., Maciag, T., Prudovsky, I., and Verdi, J.M. Soluble Jagged1 attenuates lateral inhibition allowing for the clonal expansion of neural crest stem cells. Stem Cells. 2007; 25(12):3133-3142.

Longatto Filho, A., Duarte, M. and Schmitt, F.C.Lymphangiogenesis: from the pig embryos to cancer. Journal Brasileiro de Patologia Médica. 2007;44(3):215-220.

Duarte, M., Kolev, V., Kacer, D., Graziani, I., Soldi, R., Maciag, T., and Prudovsky, I. Thrombin cleaves Jagged1, forming a soluble Jagged1 form biologically active. Molecular Biology of the Cell 2008 Nov;19(11):4863-4874.

Mota, I., Pinto, P.C.R, Novo, C., Sousa, G., Guerreiro, O., Guerra, A., Duarte, M.F., and Rodrigues, A. E. Extraction of polyphenolic compounds from Eucalyptus globulus bark: process optimization and screening for biological activity. Industrial & Engineering Chemistry Research 2012 May; 51(20):6991-7000.

Tiburcio, M., Costa, M.A.S., Duarte, M., Schmitt F.C., Longatto Fillho, A. Characterization of PAR1 and FGFR1 Expression in Invasive Breast Carcinomas: Prognostic Significance. Oncology Letters 2012; (4):647-657.

Kirov, A., Duarte, M., Guay, J., Karolak, M., Yan, C., Oxburgh, L., and Prudovsky, I. Transgenic expression of nonclassically secreted FGF suppresses kidney repair. PLoS One. 2012;7(5):e36485. Epub 2012 May 14.

Guerreiro, O., Velez, Z., Alvarenga, N., Matos, C., and Duarte, M. Molecular screening of ovine mastitis in different breeds. J Dairy Science. 2013; 96(2): 752-760.

Velez, Z., Campinho, M.A., Guerra, A., Garcia, L., Ramos, P., Guerreiro, O., Felicio, L., Schmitt, F., Duarte, M., Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities. Agriculture. 2012; 2(4): 472-492.

Ramos, P., Santos, S.A.O., Guerra, A.R., Guerreiro, O., Felicio, L., Jerónimo, E., Silvestre, A.J.D., Neto, C.P., Duarte M. Valorisation of olive mill residues antioxidant and breast cancer antiproliferative activities of hydroxytyrosol-rich extracts derived from olive oil by-products. Industrial Crops and Products 2013; (46) 359-368.

Gomes, F.P., Silva, N., Trovatti, E., Serafim L.S., Duarte, M.,Silvestre,A.J.D., Freire C.S.R. Production of Bacterial Cellulose by Gluconacetobacter sacchari using dry olive mill residue. Bioenergy and Biomass. 2013; 55:205-211.

Domingues, R.M.A., Guerra, A.R., Duarte, M., Freire, C.S.R., Neto, C.P., Silva, C.M.S., and Silvestre, A.J.D. Bioactive triterpenic acids: from agroforestry biomass residues, to promising therapeutic tools. Mini-Reviews in Organic Chemistry (in press).


Chemical Profile of Lipophilic Fractions of Different Parts of Zizyphus lotus L. by GC-MS and Evaluation of Their Antiproliferative and Antibacterial Activities

Zazouli, S; Chigr, M; Ramos, PAB; Rosa, D; Castro, MM; Jouaiti, A; Duarte, MF; Santos, SAO; Silvestre, AJD
2022, MOLECULES, 27, 2.

Metabolic Effects of a Eucalyptus Bark Lipophilic Extract on Triple Negative Breast Cancer and Nontumor Breast Epithelial Cells

Guerra, AR; Soares, BIG; Freire, CSR; Silvestre, AJD; Duarte, MF; Duarte, IF
2021, JOURNAL OF PROTEOME RESEARCH, 20, 1, 565-575.
ISBN: 1535-3907

Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids

Guerra, AR; Paulino, AF; Castro, MM; Oliveira, H; Duarte, MF; Duarte, IF
2020, BIOMOLECULES, 10, 8.
ISBN: 2218-273X

Chromatographic Separation of Phenolic Compounds from Extra Virgin Olive Oil: Development and Validation of a New Method Based on a Biphenyl HPLC Column

Ferro, MD; Santos, SAO; Silvestre, AJD; Duarte, MF
ISBN: 1422-0067

Antimicrobial activity of pomegranate peel extracts performed by high pressure and enzymatic assisted extraction

Alexandre, EMC; Silva, S; Santos, SAO; Silvestre, AJD; Duarte, MF; Saraiva, JA; Pintado, M
ISBN: 1873-7145

Biosynthesis and bioactivity of Cynara cardunculus L. guaianolides and hydroxycinnamic acids: a genomic, biochemical and health-promoting perspective

Ramos, PAB; Ferro, AM; Oliveira, MM; Goncalves, S; Freire, CSR; Silvestre, AJD; Duarte, MF
2019, PHYTOCHEMISTRY REVIEWS, 18, 2, 495-526.
ISBN: 1572-980X

Haplotype analysis of the germacrene A synthase gene and association with cynaropicrin content and biological activities in Cynara cardunculus

Ferro, AM; Ramos, P; Guerra, A; Parreira, P; Bras, T; Guerreiro, O; Jeronimo, E; Capel, C; Capel, J; Yuste-Lisbona, FJ; Duarte, MF; Lozano, R; Oliveira, MM; Goncalves, S

Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy

Guerra, AR; Duarte, MF; Duarte, IF

Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts

Ramos, PAB; Guerra, AR; Guerreiro, O; Santos, SAO; Oliveira, H; Freire, CSR; Silvestre, AJD; Duarte, MF

Eucalyptus spp. outer bark extracts inhibit Helicobacter pylori growth: in vitro studies

Parreira, P; Soares, BIG; Freire, CSR; Silvestre, AJD; Reis, CA; Martins, MCL; Duarte, MF
ISBN: 1872-633X

Usamos cookies para atividades de marketing e para lhe oferecer uma melhor experiência de navegação. Ao clicar em “Aceitar Cookies” você concorda com nossa política de cookies. Leia sobre como usamos cookies clicando em "Política de Privacidade e Cookies".