Nuno João Silva

Principal Researcher

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  • Physics

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Short CV

Nuno Silva is an accomplished physicist working among chemists with a strong research profile in magnetic nanoparticles, nanothermometers and hyperthermia. He obtained his degree in physics from the School of Sciences at the University of Porto, Portugal (1999), and his M.S. degree in Materials Sciences and Engineering from the University of Aveiro (2003). He performed research on magnetic nanoparticles towards his Ph.D. in Physics at University of Aveiro and received his degree in 2006. He then earned a Spanish Research Council Grant to develop magnetic nanoparticles for biomedical applications at the University of Zaragoza, Spain. In May 2009 Nuno decided to join CICECO at the University of Aveiro, after earning a Ciencia2008 Grant from the Portuguese Science Foundation. He gained international recognition in the field by measuring for the first time temperature at the surface of magnetic nanoparticles used as local heaters (Adv. Mater. 2010 and ACS Nano 2015), receiving an Award for encouragement of Research by The Materials Research Society of Japan in 2014. Nuno Silva has continuously made significant contributions to his field and has an outstanding track record in obtaining external funding through the national research funder FCT. Presently, he leads a group devoted to the development of magnetic nanoparticles applied to nanosensing.

Nuno co-authors 3 book chapters, 2 international patents and about 75 papers (> 2400 times cited without self-citations; h=24, ISI).

In 2001, Nuno concluded Piano and Composition studies at the Music Conservatoire of Porto.

Scientific Interests

Magnetic properties and modelling of ferrofluids, dry fluids and nanoparticles.

Magnetic nanothermometers.

Magnetic properties of nanoparticles at high pressure and high magnetic fields.

Neutron diffraction of magnetic nanoparticles.

Small Angle X-ray Scattering of nanohybrids, nanoparticles and ferrofluids.

Selected Publications

“Temperature-switch nanomagnetic logic gates for cellular hyperthermia”, R Oliveira-Silva, R.A. Pereira, F. M. Silva, V.M. Gaspar, A. Ibarra, A. Millán, F.L. Sousa, J.F. Mano and N.J.O. Silva*, Mater. Horiz.  (2019), http://doi.org/10.1039/C8MH01510D  
1royal_society_of_chemistry_animated.gif

PCT/IB2018/053697, Probe Element and Methods for Separation and Sensing of Analytes Controlled by Temperature, Inventors: de Oliveira e Silva, Nuno João; Oliveira-Silva, Rui Pedro. https://www.wipo.int/patentscope/search/en/WO2018215970

  
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“Implementing Thermometry on Silicon Surfaces Functionalized by Lanthanide-Doped Self-Assembled Polymer Monolayers” M. Rodrigues, R. Piñol, G. Antorrena, C.D.S. Brites, N.J.O. Silva, J. L. Murillo, R. Cases, I. Díez, F. Palacio, N. Torras, J. A. Plaza, L. Pérez-García, L. D. Carlos,* and A. Millán* Adv. Funct. Mater. 26, 200–209 (2016)http://doi.org/10.1002/adfm.201503889

 11advfuncmater_logic.png
 “Joining Time-Resolved Thermometry and Magnetic-Induced Heating in a Single Nanoparticle Unveils Intriguing Thermal Properties” R. Piñol, C.D.S. Brites, R. Bustamante, A. Martínez, N.J.O. Silva, J.L. Murillo, R. Cases, J. Carrey, C. Estepa, C. Sosa, F. Palacio, L.D. Carlos* and A Millan*, ACS Nano 9, 3134 (2015). https://pubs.acs.org/doi/abs/10.1021/acsnano.5b00059  111acsnano_cells.png

"Magnetically responsive Dry Fluids" F. L. Sousa*, R. Bustamante, A. Millan, F. Palacio, T. Trindade and N.J.O. Silva*, Nanoscale, 2013 (communication)http://doi.org/10.1039/C3NR01784B

 "Shell pressure on the core of MnO/Mn3O4 core/shell nanoparticles" N.J.O. Silva*, M. Karmaoui, V. S. Amaral, I. Puente-Orench, J. Campo, I. da Silva, A. Ibarra, R. Bustamante, A. Millán and F. Palacio, Phys. Rev. B 87, 224429 (2013) http://dx.doi.org/10.1103/PhysRevB.87.224429


 "Synthesis of cobalt aluminate nanopigments by non-aqueous sol-gel route" M. Karmaoui*, N.J.O. Silva*, V.S. Amaral, A. Ibarra, A. Millán and F. Palacio, Nanoscale 5, 4277 (2013) http://dx.doi.org/10.1039/C3NR34229H  

 “Thermometry at the Nanoscale”, C.D.S. Brites, P.P. Lima, N.J.O. Silva, A. Millán, V.S. Amaral, F. Palacio*, and L.D. Carlos*, Nanoscale, 2012 (invited review) http://dx.doi.org/10.1039/C2NR30663H  
 “Magnetic and Relaxation Properties of Multifunctional Polymer-Based Nanostructured Bioferrofluids as MRI Contrast Agents” H. Amiri, R. Bustamante, A.Millan, N.J.O. Silva, R. Pinol, L. Gabilondo, F. Palacio, P. Arosio, M. Corti, and A. Lascialfari, Magn. Res. Med. 66, 1715-1721 (2011) http://dx.doi.org/10.1002/mrm.22959  
 “Shifted loops and coercivity from field imprinted high energy barriers in ferritin and ferrihydrite nanoparticles” N.J.O. Silva*, V.S. Amaral, A. Urtizberea, R. Bustamante, A. Millán, F. Palacio, E. Kampert and U. Zeitler, S. de Brion, O. Iglesias and A. Labarta, Phys. Rev. B 84, 104427 (2011) http://link.aps.org/doi/10.1103/PhysRevB.84.104427  
 "A Luminescent Molecular Thermometer for Long-Term Absolute Temperature Measurements at the Nanoscale" C.D.S. Brites, P.P. Lima, N.J.O. Silva, A. Millan, V.S. Amaral, F. Palacio* and L.D. Carlos*" Adv. Mater. (2010) http://dx.doi.org/10.1002/adma.201001780  

 
 "Remanent magnetization in CoO antiferromagnetic nanoparticles" N.J.O. Silva*, A. Millán, F. Palacio, M. Martins, T. Trindade, I. Puente-Orench and J. Campo, Phys. Rev. B 82, 094433 (2010) http://dx.doi.org 10.1103/PhysRevB.82.094433  
 “Surface and core magnetic anisotropy in maghemite nanoparticles determined by pressure experiments” Y. Komorida*, M. Mito, H. Deguchi, and S. Takagi, A. Millán, N. J. O. Silva* and F. Palacio, Appl. Phys. Lett. 94, 202503 (2009) http://dx.doi.org/10.1063/1.3131782  
 “Temperature dependence of antiferromagnetic susceptibility in ferritin”, N.J.O. Silva*, A. Millan, F. Palacio, E. Kampert, U. Zeitler, and V. S. Amaral, Phys. Rev. B 79, 104405 (2009). http://dx.doi.org/10.1103/PhysRevB.79.104405  

 
 “Nanoscopic photoluminescence memory as a fingerprint of complexity in self-assembled alkylene/siloxane hybrids” L.D. Carlos*, V. de Zea Bermudez*, V.S. Amaral, S.C. Nunes, N.J.O. Silva, R.A. Sá Ferreira, J. Rocha, C.V. Santilli, D. Ostrovskii, Adv. Mater. 19, 341-348 (2007). http://dx.doi.org/10.1002/adma.200601435  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Main present collaborators

A. Millán and R. Piñol (Instituto de Ciencia de Materiales de Aragón/CSIC, Zaragoza https://www.researchgate.net/profile/A_Millan

A. Lascialfari (University of Milan and University of Pavia, Italy) https://scholar.google.it/citations?user=D5iAO2sAAAAJ&hl=en

V. M. Gaspar (CICECO, Universidade de Aveiro) http://www.ciceco.ua.pt/vitorgaspar

S. Ohkoshi (School of Sciences, University of Tokyo) http://www.chem.s.u-tokyo.ac.jp/users/ssphys/english/

I. Puente-Orench Institut Laue-Langevin and Instituto de Ciencia de Materiales de Aragón CSIC - Universidad de Zaragoza) https://www.researchgate.net/scientific-contributions/2034280793_Ines_Puente-Orench 

M. Mito (Kyushu Institute of Technology, Kitakyushu, Japan) https://www.researchgate.net/scientific-contributions/22173712_Masaki_Mito

teaching

Nanodevices and Nanomagnetism

https://www.ua.pt/ensino/uc/4468

 

Propriedades físicas dos materiais

https://www.ua.pt/uc/4207

Ongoing Supervisions

Bruna Alexandra Lopes Tavares

Research Fellowship

Eduardo T C Coimbra e Silva

PhD Student

Gabriel Cardoso Pinto

Post-Doc Fellowship

Gabriela Ferreira Resende

PhD Student

Hamid Khoshdel

PhD Student

Joana Filipa Lunet Soeiro

PhD Student

João Miguel Lopes Costa

PhD Student

Jéssica Silva Santana

PhD Student

Tehseen Ali Anjum

PhD Student

Projects

3D temperature mapping critical to understanding the nanoworld (ThermoRise)

CoordinatorEuropean Comission
Nanometre-scale devices capable of measuring temperature variations at a molecular level are valuable in both fundamental and applied science. For example, they can quickly measure micromachine overheating or the temperature inside of a cell. Although they hold tremendous promise for many applications, their 2D resolution has been a limiting fac...

A functional device for sub-micron temperature mapping under magnetic field (EXPL/CTM-NAN/0295/2012 )

CoordinatorFundação para a Ciência e a Tecnologia
nanothermometer luminescent materials nanomagnetism functional device

Controlling the length scale through "Chimie Douce": from inorganic functional materials to organic-inorganic hybrids (POCTI/CTM/46780/2002)

PartnerFundação para a Ciência e a Tecnologia
Functional Inorganic Materials Chimie Douce Organic-Inorganic Hybrids Luminescence

Desenvolvimento de fontes de arrefecimento controladas remotamente para uma nanotermodinâmica aplicada (CoolPoint)

CoordinatorFundação para a Ciência e a Tecnologia
We propose to prepare and develop micro- and nanometer-structured materials acting as local cooling sources operating at near room temperature, i. e., materials able to locally absorb heat and in which the absorption process is triggered and controlled from a distance. We also propose to develop a proof of concept device able to manipulate heat ...

Desenvolvimento e aplicação de nanomagnetes e ferrofluidos com variação on-to-off da magnetização em torno da temperatura ambiente. (On2OffNanoMagnets)

CoordinatorFundação para a Ciência e a Tecnologia

Development of 4D wireless thermometry to target tumor ablation (PTDC/NAN-MAT/3901/2020)

CoordinatorFundação para a Ciência e a Tecnologia
Thermography Magnetic Nanoparticles Induced Hyperthermia Bioprinting

Facing the challenges of characterizing novel thermal materials and processes (Heat@UA) (RECI/CTM-CER/0336/2012)

PartnerFundação para a Ciência e a Tecnologia
Thermal properties of materials Thermal processes Thermometry Nano-scale studies

Multidimensional thermal rectifiers based on assembly of anisotropic polyoxometalates (THERMOPOMs)

PartnerFundação para a Ciência e a Tecnologia
Herein, we propose to prepare and develop micro- and nanometer organic-inorganic hybrid structures acting as two dimensional (2D) thermal rectifiers, i. e., materials exhibiting anisotropic morphology and having a thermal conductivity that depends on the direction of the heat flow.

Organic-inorganic hybrids with enhanced light-emitting properties for the new generation of optical communications (PTDC/CTM/101324/2008)

PartnerFundação para a Ciência e a Tecnologia
Organic-inorganic hybrids Light emitting devices Optical filtering Optical amplification

Síntesis, caracterización magnética y modelización atomística de nanopartículas de óxidos metálicos (Acção integrada Luso-Espanhola E-42/11)

CoordinatorOther National

Publications

Advances in screening hyperthermic nanomedicines in 3D tumor models

Soeiro, JF; Sousa, FL; Monteiro, MV; Gaspar, VM; Silva, NJO; Mano, JF
2024, NANOSCALE HORIZONS, 9, 3, 334-364.
ISBN: 2055-6764

Evaluation of the alternating magnetic field (AMF) influence in catalytic activities of enzymes immobilized into magnetic graphene oxide: A new approach

Pinto, GC; Lucena, GN; Piazza, RD; Costa, JML; Silva, ETCC; Gu, YY; de Paula, AV; Silva, NJO; Marques, RFC
2023, MATERIALS TODAY COMMUNICATIONS, 36.

Ex-situ magnetic activated carbon for the adsorption of three pharmaceuticals with distinct physicochemical properties from real wastewater

Pereira, D; Gil, MV; Esteves, VI; Silva, NJO; Otero, M; Calisto, V
2023, JOURNAL OF HAZARDOUS MATERIALS, 443.

In situ functionalization of a cellulosic-based activated carbon with magnetic iron oxides for the removal of carbamazepine from wastewater

Pereira, D; Rocha, LS; Gil, MV; Otero, M; Silva, NJO; Esteves, VI; Calisto, V
2021, ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28, 15, 18314-18327.
ISBN: 1614-7499

Screening of dual chemo-photothermal cellular nanotherapies in organotypic breast cancer 3D spheroids

Ferreira, LP; Gaspar, VM; Monteiro, MV; Freitas, B; Silva, NJO; Mano, JF
2021, JOURNAL OF CONTROLLED RELEASE, 331, 85-102.
ISBN: 1873-4995

Efficient Brownian oscillators and nanoheaters based on gallium-doped epsilon-Fe2O3

Gu, YY; Silva, NJO; Yoshikiyo, M; Namai, A; Pinol, R; Maurin-Pasturel, G; Cui, YW; Ohkoshi, SI; Millan, A; Martinez, A
2021, CHEMICAL COMMUNICATIONS, 57, 18, 2285-2288.
ISBN: 1364-548X

Temperature-responsive nanomagnetic logic gates for cellular hyperthermia

Silva, RO; Pereira, RA; Silva, FM; Gaspar, VM; Ibarra, A; Millan, A; Sousa, FL; Mano, JF; Silva, NJO
2019, MATERIALS HORIZONS, 6, 3, 524-530.
ISBN: 2051-6355

Density Gradient Selection of Colloidal Silver Nanotriangles for Assembling Dye-Particle Plasmophores

Oliveira-Silva, R; Sousa-Jeronimo, M; Botequim, D; Silva, NJO; Prazeres, DMF; Paulo, PMR
2019, NANOMATERIALS, 9, 6.

Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications

Bastos, AR; Vicente, CMS; Oliveira-Silva, R; Silva, NJO; Tacao, M; da Costa, JP; Lima, M; Andre, PS; Ferreira, RAS
2018, SENSORS, 18, 3.

Implementing Thermometry on Silicon Surfaces Functionalized by Lanthanide-Doped Self-Assembled Polymer Monolayers

Rodrigues, M; Pinol, R; Antorrena, G; Brites, CDS; Silva, NJO; Murillo, JL; Cases, R; Diez, I; Palacio, F; Torras, N; Plaza, JA; Perez-Garcia, L; Carlos, LD; Millan, A
2016, ADVANCED FUNCTIONAL MATERIALS, 26, 2, 200-209.

Nanoscale Thermometry for Hyperthermia Applications

In Raluca Maria Fratila, Jesús Martínez De La Fuente (Eds.), Nanomaterials for Magnetic and Optical Hyperthermia Applications
Rafael Piñol, Carlos D.S. Brites, Nuno J. Silva, Luis D. Carlos, Angel Millán
2019, 139-172, Elsevier.
ISBN: 978-0-12-813928-8

Chapter 8:Organic–Inorganic Hybrids Thermometry

In Luís Dias Carlos, Fernando Palacio (Eds.), Thermometry at the Nanoscale : Techniques and Selected Applications
Angel Millán, Luís D. Carlos, Carlos D. S. Brites, Nuno J. O. Silva, Rafael Piñol and Fernando Palacio
2016, 237-272, Royal Society of Chemistry.
ISBN: 978-1-84973-904-7

Bionanocomposites for Magnetic Removal of Water Pollutants

In Vijay Kumar Thakur; Manju Kumari Thakur (Eds.), Eco-friendly polymer nanocomposites: chemistry and applications
F. L. Sousa, A. L. Daniel-da-Silva, N. J. O. Silva, T. Trindade
2015, 279-310, New Delhi, Springer India.
ISBN: 978-81-322-2472-3

Patents

Luminescent organic/inorganic matrix, method for the production thereof and luminescent molecular thermometer based on said matrix

Devices International

Palacio, Fernando; Escolano, Angel; Silva, Nuno; Carlos, Luis ; Amaral, Vitor; Lima, Patricia; Brites, Carlos

Luminescent organic/inorganic matrix that contains tris(beta-diketonate) complexes of cations of two different lanthanides (europium and terbium). Optionally, the matrix comprises coated magnetic iron-oxide nanoparticles. The matrix may be composed of inorganic polymers based on siloxane that are derivatized with organic groups (for exa...

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