abstract
There has been a great deal of interest in the use of nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as bacterial cellulose does not intrinsically present antimicrobial properties, in the present study, antimicrobial bacterial cellulose membranes were obtained by chemical grafting of aminoalkyl groups onto the surface of its nanofibrillar network. This approach intends to mimic intrinsic antimicrobial properties of chitosan. Interestingly, these novel grafted bacterial cellulose membranes (BC-NH2) are simultaneously lethal against S. aureus and E. coli and nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus may be useful for biomedical applications. In addition to these biological properties, the bioactive nanostructured BC-NH2 membranes also present improved mechanical and thermal properties.
keywords
ANTIBACTERIAL ACTIVITY; COUPLING AGENTS; CHITOSAN; FIBERS; PROTEINS; CELLS; FILMS
subject category
Science & Technology - Other Topics; Materials Science
authors
Fernandes, SCM; Sadocco, P; Aonso-Varona, A; Palomares, T; Eceiza, A; Silvestre, AJD; Mondragon, I; Freire, CSR
our authors
Armando Jorge Domingues Silvestre
Full professor
Carmen Sofia da Rocha Freire Barros
Coordinating ResearcherProjects
RMNE-UA-National Network of Electron Microscopy (REDE/1509/RME/2005 )
acknowledgements
S.C.M.F. thanks FCT for funding her Postdoctoral Research Grant (SFRH/BPD/70119/2010) cofinancing by POPH/ESF program. The authors thank CICECO (Pest-C/CTM/LA0011/2011) and FCT for funding within the scope of the