Metabolic profiling of biofluids: potential in lung cancer screening and diagnosis
authors Duarte, IF; Rocha, CM; Gil, AM
nationality International
journal EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
author keywords biofluid; lung cancer; metabolomics; metabonomics; MS; NMR; plasma; serum; urine
keywords MASS-SPECTROMETRY; NMR-SPECTROSCOPY; EXHALED BREATH; BLOOD-PLASMA; BIOMARKERS; METABONOMICS; SERUM; CHROMATOGRAPHY; SIGNATURES; MORTALITY
abstract The knowledge that the organism's metabolome is a potentially informative mirror of the impact of disease and its dynamics has led to promising developments in cancer research, strongly geared toward the discovery of new biomarkers of disease onset and progression. The present text reviews the advances made in the last 10 years in lung cancer research making use of the metabolomics strategies, particularly concerning metabolite profiling of human biofluids (blood serum and plasma, urine and others), expected to reflect the deviant metabolic behavior of lung tumors. The main goal of this article is to provide the reader with an up-to-date summary of the main metabolic variations taking place in biofluids, in relation to lung cancer, as well as of the analytical strategies employed to unveil them. Furthermore, particular needs and challenges are identified and possible developments envisaged.
publisher EXPERT REVIEWS
issn 1473-7159
year published 2013
volume 13
issue 7
beginning page 737
ending page 748
digital object identifier (doi) 10.1586/14737159.2013.835570
web of science category Pathology
subject category Pathology
unique article identifier WOS:000331288900015
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.096
5 year journal impact factor 3.652
category normalized journal impact factor percentile 83.974
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