abstract
Materials filled with a silicate glass (MSi) and a borate glass (MB) were developed and compared in terms of their invitro behavior. The effect of filler composition and concentration (0, 30, 40 and 50wt%) on the curing parameters, residual monomer, water uptake, weight loss, bioactivity, mechanical properties (bending and compression) and osteoblast cytocompatibility was evaluated. The addition of bioactive glass filler significantly improved the cements curing parameters and the mechanical properties. The most relevant results were obtained for the lower filler concentration (30wt%) a maximum flexural strength of 40.4MPa for MB3 and a maximum compressive strength of 95.7MPa for MSi3. Invitro bioactivity in acellular media was enhanced by the higher glass contents in the cements. Regarding the biological assessment, the incorporation of the silicate glass significantly improved osteoblast cytocompatibility, whereas the presence of the borate glass resulted in a poor cell response. Nevertheless it was shown that the surviving cells on the MB surface were in a more differentiated stage compared to those growing over non-filled poly(methyl methacrylate). Results suggest that the developed formulations offer a high range of properties that might be interesting for their use as self-curing cements.
keywords
BONE CEMENTS; MECHANICAL-PROPERTIES; CERAMIC FILLERS; HYDROXYAPATITE; BIOACTIVITY; BIOCOMPATIBILITY; COMPOSITES; ACTIVATORS; TCP; HA
subject category
Engineering; Materials Science
authors
Lopes, PP; Garcia, MP; Fernandes, MH; Fernandes, MHV
our authors
Maria Helena Figueira Vaz Fernandes
Retired Professoracknowledgements
This work was financed and supported by the Portuguese Foundation for Science and Technology (FCT).