abstract
Complexes of the type trans-[PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved.
keywords
TUBERCULOSIS PANTOTHENATE SYNTHETASE; ALAMAR BLUE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; PALLADIUM(II) COMPLEXES; BIOLOGICAL EVALUATION; STRUCTURAL-CHARACTERIZATION; SUPRAMOLECULAR CHEMISTRY; N BOND; LIGANDS; INHIBITORS
subject category
Chemistry; Crystallography
authors
da Silva, C; Ribeiro, LB; Furuno, CC; da Cunha, GA; de Souza, RFF; Netto, AVG; Mauro, AE; Frem, RCG; Fernandes, JA; Paz, FAA; Marino, LB; Pavan, FR; Leite, CQF
our authors
Filipe Alexandre Almeida Paz
Principal Researcher
José Alberto Pires Fernandes
Post-doc Fellowshipacknowledgements
This work was sponsored by Grants from FAPESP 2012/15486-3, CNPq and CAPES. This work was also developed in the scope of the project CICECO-Aveiro Institute of Materials (Ref. FCT UID/CTM /50011/2013), financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. FCT is acknowledge for specific funding of the purchase of the single-crystal X-ray diffractometer. The FCT and the European Social Fund are acknowledged for grant SFRH/BPD/63736/2009 (to JAF).