abstract
Compounds [{Ag(phen)(mu-tu)}(2)](NO3)(2) (1), [{Ag(phen)(mu-tu)}(2)](CF3SO3)(2) (2), [{Ag(bpy)(mu-tu)}(2)](NO3)(2) (3) (where phen = 1,10-phenanthroline; bpy = 2,2'-bipyridine; tu = thiourea) were prepared by reacting the appropriate AgX salt (X- = NO3-, CF3SO3-), the N,N-chelating ligand (phen or bpy) and thiourea in a ca. 1:1:2 M ratio, respectively. The silver(l) complexes were characterized by elemental analysis, infrared (IR), H-1 and C-13 NMR spectroscopies, MS/ESI and conductivity measurements. The IR and NMR data were consistent with the presence of chelating phen (1 and 2) and bpy (3) ligands and demonstrated the S-coordination mode of thiourea. The crystal and molecular structures of compound [{Ag(bpy)(mu-tu)}(2)] (NO3)(2) (3) were determined by single-crystal X-ray diffraction. The complexes 1-3 were screened for their in vitro antimycobacterial (Mycobacterium tuberculosis), antileishmanial (Leishmania (L) amazonensis), antibacterial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), antifungal activities (Candida albi cans, Candida tropicalis, Candida krusei). (C) 2014 Elsevier Ltd. All rights reserved.
keywords
ANTIMICROBIAL ACTIVITIES; CRYSTAL-STRUCTURES; IN-VITRO; SPECTROSCOPIC CHARACTERIZATION; TRIPHENYLPHOSPHINE LIGANDS; MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL ACTIVITY; LEISHMANICIDAL ACTIVITY; SUBSTITUTED THIOUREAS; COORDINATION POLYMERS
subject category
Chemistry; Crystallography
authors
Segura, DF; Netto, AVG; Frem, RCG; Mauro, AE; da Silva, PB; Fernandes, JA; Paz, FAA; Dias, ALT; Silva, NC; de Almeida, ET; Marques, MJ; de Almeida, L; Alves, KF; Pavan, FR; de Souza, PC; de Barros, HB; Leite, CQF
our authors
Filipe Alexandre Almeida Paz
Principal Researcher
José Alberto Pires Fernandes
Post-doc Fellowshipacknowledgements
This research was supported by CNPq 487092/2012-0, FAPESP, CAPES and FAPEMIG. Some of the authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal), FEDER (Portugal) and COMPETE for the financial support towards the purchase of the single-crystal diffractometer, for the post-doctoral research grant No. SFRH/BPD/63736/2009 (to JAF), and for funding the R&D project PTDC/QUI-QUI/098098/2088 (FCOMP-01-0124-FEDER-010785).