Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case Control Study

abstract

This work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consideration in unmatched subject groups. Premature newborns are, however, characterized by a stronger signature of varying metabolites, suggestive of disturbances in nucleotide metabolism, lung surfactants biosynthesis and renal function, along with enhancement of tricarboxylic acid (TCA) cycle activity, fatty acids oxidation, and oxidative stress. Comparison with other abnormal conditions (respiratory depression episode, large for gestational age, malformations, jaundice and premature rupture of membranes) reveals that such signature seems to be largely specific of preterm newborns, showing that NMR metabolomics can retrieve particular disorder effects, as well as general stress effects. These results provide valuable novel information on the metabolic impact of prematurity, contributing to the better understanding of its effects on the newborn's state of health.

keywords

INTRAUTERINE GROWTH-RETARDATION; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; MAGNETIC-RESONANCE-SPECTROSCOPY; NMR-BASED METABONOMICS; BIRTH-WEIGHT INFANTS; OXIDATIVE STRESS; INBORN-ERRORS; PRETERM NEWBORNS; H-1-NMR; PREGNANCY

subject category

Biochemistry & Molecular Biology

authors

Diaz, SO; Pinto, J; Barros, AS; Morais, E; Duarte, D; Negrao, F; Pita, C; Almeida, MD; Carreira, IM; Spraul, M; Gil, AM

our authors

acknowledgements

This work was developed within the scope of the project CICECO-Aveiro Institute of Materials (FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and cofinanced by FEDER under the PT2020 Partnership Agreement and QOPNA FCT-Funding: PEst-C/QUI/UI0062/2013. S.D. thanks FCT for the SFRH/BD/64159/2009 grant. JP thanks FCT for the SFRH/BD/73343/2010 and Bruker BioSpin grants. D.D. acknowledges funds from the Observatoire Hommes-Milieux International (OHM.I)

Share this project:

Related Publications

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".