abstract
This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(epsilon-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with Ag2O and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0.25%, 0.5% and 0.75 wt%). The composite membranes were characterized in terms of morphology, fiber diameter, weight loss, mineralization potential and mechanical performance. (C) 2017 Elsevier B.V. All rights reserved.
keywords
IN-VITRO BIOACTIVITY; BIODEGRADABLE POLYMERS; MECHANICAL-PROPERTIES; SURGICAL SUTURES; COBALT OXIDES; SCAFFOLDS; NANOPARTICLES; FIBERS; SILVER; NANOFIBERS
subject category
Materials Science
authors
Moura, D; Souza, MT; Liverani, L; Rella, G; Luz, GM; Mano, JF; Boccaccini, AR
our authors
João Mano
Vice Directoracknowledgements
The authors acknowledge the European program FEDER/COMPETE for the financial support through project Matryoshkas: PTDC/CTM-BIO/1814/2012.; Liliana Liverani acknowledges funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sktodowska-Curie grant agreement no. 657264.