abstract
Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse,origins. This critical review offers a compilation on the main results achieved by the use of ionic liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to Separation processes and by suggesting some steps to overcome the current limitations.
keywords
AQUEOUS 2-PHASE SYSTEMS; ULTRASONIC-ASSISTED EXTRACTION; SOLID-PHASE EXTRACTION; BOVINE SERUM-ALBUMIN; ACID METHYL-ESTERS; CITRUS ESSENTIAL OIL; 3-PHASE PARTITIONING ILTPP; SALVIA-MILTIORRHIZA-BUNGE; FLAVUM CR. PAPAVERACEAE; COUNTER-CURRENT CHROMATOGRAPHY
subject category
Chemistry
authors
Ventura, SPM; Silva, FAE; Quental, MV; Mondal, D; Freire, MG; Coutinho, JAP
our authors
Ana Francisca Osório de Almeida Coelho e Silva
Junior Researcher
Dibyendu Mondal
Post-doc Fellowship
Mara Guadalupe Freire Martins
Coordinating Researcher
Maria João Quental
Post-Doc Fellowship
Sónia Patrícia Marques Ventura
Assistant ProfessorGroups
G1 - Porous Materials and Nanosystems
G4 - Renewable Materials and Circular Economy
G5 - Biomimetic, Biological and Living Materials
Projects
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)
Projeto de Investigação Exploratória: Sónia Patricia Marques Ventura (IF/00402/2015)
Igy Technology: A Purication Platform using Ionic-Liquid-Based Aqueous Biphasic Systems (IGYPURTECH)
acknowledgements
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT ref. UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when appropriate cofinanced by FEDER under the PT2020 Partnership Agreement. The authors acknowledge FCT for the IF contract IF/00402/2015 of S.P.M.V. and the doctoral grants SFRH/BD/94901/2013 and SFRH/BD/100155/2014 of F.A.e.S. and M.V.Q, respectively. M.G.F. acknowledges the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant 337753.