Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

authors	Ventura, SPM; Silva, FAE; Quental, MV; Mondal, D; Freire, MG; Coutinho, JAP
nationality	International
journal	CHEMICAL REVIEWS
keywords	AQUEOUS 2-PHASE SYSTEMS; ULTRASONIC-ASSISTED EXTRACTION; SOLID-PHASE EXTRACTION; BOVINE SERUM-ALBUMIN; ACID METHYL-ESTERS; CITRUS ESSENTIAL OIL; 3-PHASE PARTITIONING ILTPP; SALVIA-MILTIORRHIZA-BUNGE; FLAVUM CR. PAPAVERACEAE; COUNTER-CURRENT CHROMATOGRAPHY
abstract	Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse,origins. This critical review offers a compilation on the main results achieved by the use of ionic liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to Separation processes and by suggesting some steps to overcome the current limitations.
publisher	AMER CHEMICAL SOC
issn	Sep-65
isbn	1520-6890
year published	2017
volume	117
issue	10
beginning page	6984
ending page	7052
digital object identifier (doi)	10.1021/acs.chemrev.6b00550
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000402498700008