Syntheses of Zn(II) and Cu(II) Schiff base complexes using N,O donor Schiff base ligand: Crystal structure, DNA binding, DNA cleavage, docking and DFT study
authors Ghorai, P; Saha, R; Bhuiya, S; Das, S; Brandao, P; Ghosh, D; Bhaumik, T; Bandyopadhyay, P; Chattopadhyay, D; Saha, A
nationality International
journal POLYHEDRON
author keywords Zn(II) and Cu(II) Schiff base complexes; Crystal structure; DNA binding and cleavage studies; DFT calculations; Molecular docking analysis
keywords DENSITY-FUNCTIONAL THEORY; EFFECTIVE CORE POTENTIALS; SET MODEL CHEMISTRY; IN-VITRO; MOLECULAR CALCULATIONS; EXCITATION-ENERGIES; COPPER(II) COMPLEX; CYTOTOXIC ACTIVITY; SELECTIVE BINDING; ANTIVIRAL AGENTS
abstract Two mononuclear Schiff base complexes, [Zn(L)(2)] (1) and [Cu(L)(2)] (2) are synthesized involving bidentate N,O-donor ligand viz. 2-((E)-(3-methoxypropylimino)methyl)-6-methoxyphenol. Different spectroscopic tools like FTIR, UV-Vis, H-1 NMR, C-13 NMR etc. have been deployed to characterize complexes 1 and 2. Complex 1 has been analyzed using single crystal X-ray diffraction analysis method. Complexes 1 and 2 show affinity towards A-T rich sequence of DNA which is further supported by molecular docking analysis. Interestingly, only complex 2 exhibits oxidative DNA cleavage activity in presence of H2O2 which is investigated by gel electrophoresis method. Complex I is found to be nontoxic whereas complex 2 is cytotoxic. (C) 2017 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0277-5387
year published 2018
volume 141
beginning page 153
ending page 163
digital object identifier (doi) 10.1016/j.poly.2017.11.041
web of science category Chemistry, Inorganic & Nuclear; Crystallography
subject category Chemistry; Crystallography
unique article identifier WOS:000424961200022
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