abstract
The solvatochromic solvent parameters characterizing the solvent polarity (pi*), solvent hydrogen-bond donor acidity (alpha), and solvent hydrogen-bond acceptor basicity (beta) of aqueous media were measured in the coexisting phases of nine different aqueous polymer/polymer two-phase systems (ATPS), containing 0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4. Partitioning coefficients of six neutral compounds were measured in the nine ATPS at particular polymer Concentrations. The solvatochromic equation was used to describe the partitioning of each Compound. Three descriptors of the solvent properties of the phases Could describe adequately the partitioning of the solutes in all the ATPS employed.
keywords
SOLVATOCHROMIC COMPARISON METHOD; SOLVATION ENERGY RELATIONSHIPS; BIPHASIC SYSTEMS; POLY(ETHYLENE GLYCOL); POLYETHYLENE-GLYCOL; ORGANIC-MOLECULES; METHYLENE GROUP; PI-STAR; ALPHA; SCALE
subject category
Chemistry
authors
Madeira, PP; Reis, CA; Rodrigues, AE; Mikheeva, LM; Zaslavsky, BY
our authors
Pedro António Palma Madeira
Junior Researcheracknowledgements
We thank Professor A H. Abraham (University College London) for helpful discussions and for reviewing the manuscript. PPM acknowledges Prof. Eugenia Macedo (LSRE-Porto) for the use of her equipment to measure solvatochromic data. P.P.M. acknowledges financial Support (Grant SFRH/BPD/45055/2008) from Fundacao Para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal.