authors |
Saidi, L; Rocha, DHA; Talhi, O; Bentarzi, Y; Nedjar-Kolli, B; Bachari, K; Paz, FAA; Helguero, LA; Silva, AMS |
nationality |
International |
journal |
CHEMMEDCHEM |
author keywords |
benzophenones; cancer; cytotoxicity; drug design; synthesis design |
keywords |
1,3-BIS-SILYL ENOL ETHERS; ALDOL REACTIONS; DERIVATIVES; INHIBITORS; XANTHONES; PYRIDINE; ANALOGS |
abstract |
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 mu m) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects. |
publisher |
WILEY-V C H VERLAG GMBH |
issn |
1860-7179 |
isbn |
1860-7187 |
year published |
2019 |
volume |
14 |
issue |
10 |
beginning page |
1041 |
ending page |
1048 |
digital object identifier (doi) |
10.1002/cmdc.201900127 |
web of science category |
Chemistry, Medicinal; Pharmacology & Pharmacy |
subject category |
Pharmacology & Pharmacy |
unique article identifier |
WOS:000468773400007
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
3.124 |
5 year journal impact factor |
3.113 |
category normalized journal impact factor percentile |
61.122 |
dimensions (citation analysis):
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altmetrics (social interaction):
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