1,2,4-Triphenylpyrroles: Synthesis, Structure and Luminescence Properties

abstract

Pyrroles are widely found in natural products and play an important role in biological processes. Certain pyrrole derivatives are fluorescent and may be used as molecular probes or biomarkers in the diagnosis of diseases, such as Alzheimer's or Parkinson's. Herein is reported the synthesis of five new pyrrole derivatives bearing phenyl rings on positions 1, 2, and 4, with electron-donating groups at the periphery. The introduction of more or stronger electron-donating groups red-shifts and increases the efficiency of the fluorescence emission.

keywords

AGGREGATION-INDUCED EMISSION; ENHANCEMENT; DERIVATIVES; PYRROLE; DISCOVERY; DESIGN

subject category

Chemistry

authors

Ferreira, JRM; da Silva, RN; Rocha, J; Silva, AMS; Guieu, S

our authors

acknowledgements

Thanks are due to the University of Aveiro, FCT/MEC for financial support to the QOPNA research Unit (FCT UID/QUI/00062/2019), CICECO-Aveiro Institute of Materials (FCT Ref. UID/CTM/50011/2019), financed by national funds through FCT/MEC, and also to the Portuguese NMR Network. This work was also supported by the Integrated Programme of SR&TD 'pAGE - Protein Aggregation Across the Lifespan' (reference CENTRO-01-0145-FEDER-000003), co-funded by the Centro 2020 program, Portugal 2020, and the European Union, through the European Regional Development Fund.

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