abstract
The synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu-4[(mu(3)-thiocrome)(2)Cl-4]center dot 2(H2O)}(n) 1, and Cu-2[(mu(2)-thiocrome)(2)Cl-2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain structure based on the linkage of two crystallographic different copper centers and thiochrome ligand through the N(1), N (2) and N(3) nitrogen atoms. Compound 2 is a 0D dimeric copper structure assembled by two thiochrome ligands. For both compounds, the copper(I) centers exhibits a distorted trigonal pyramidal geometry. The antitumor capacity of both compounds was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability. The two compounds showed similar IC50 values, and were slightly more potent than cisplatin, against the same cell line.
keywords
COPPER-COMPLEXES SYNTHESIS; METAL-ION INTERACTIONS; CRYSTAL-STRUCTURE; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CYTOTOXIC PROPERTIES; MOLECULAR-STRUCTURE; ANTITUMOR-ACTIVITY; 2 SALTS; THIAMINE
subject category
Chemistry
authors
Brandao, P; Guieu, S; Correia-Branco, A; Silva, C; Martel, F
our authors
Paula Cristina Ferreira da Silva Brandão
Assistant Researcher
Samuel Jacques André Guieu
Junior Researcheracknowledgements
The authors want to thank University of Aveiro, Institute of materials (CICECO) and the Department of Chemistry from Portugal for supporting this work.; Thanks are due to University of Aveiro, FCT/MEC for the financial support to the QOPNA research Unit (FCT UID/QUI/00062/2013) and CICECO-Aveiro Institute of Materials (POCI-01-0145-FEDER-007679; FCT-UID/CTM/50011/2013), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement, and also to the Portuguese NMR Network. S. Guieu also thanks the pAge project: Life-long protein aggregation (Centro-01-0145-FEDER-000003) and acknowledges the financial support from the European Union Framework Programme for Research and Innovation HORIZON 2020, under the TEAMING Grant agreement No 739572 - The Discoveries CTR.