Chirality-Dependent Growth of Self-Assembled Diphenylalanine Microtubes

abstract

The difference in the crystal structure and growth kinetics of microtubes formed from L- and D-enantiomers of diphenylalanine dipeptide is investigated both experimentally and theoretically by computer simulation. The microtubes of and D-enantiomers grown simultaneously and under identical experimental conditions possess different crystallographic space groups, have essential difference in sizes, and demonstrate different growth kinetics. Computer simulation by molecular mechanics methods revealed a fundamental difference in the interaction between structural units of microtubes of different chiralities. A model describing chirality-dependent growth of microtubes is proposed.

keywords

PEPTIDE NANOTUBES; SPIN SELECTIVITY; PHYSICAL-PROPERTIES; ENANTIOMERS; MOLECULES

subject category

Chemistry; Crystallography; Materials Science

authors

Zelenovskiy, PS; Nuraeva, AS; Kopyl, S; Arkhipov, SG; Vasilev, SG; Bystrov, VS; Gruzdev, DA; Waliczek, M; Svitlyk, V; Shur, VY; Mafra, L; Kholkin, AL

our authors

acknowledgements

The measurements of microtubes growth kinetics and morphology analysis were done in Ural Federal University (UrFU). This part of the research was made possible by Russian Science Foundation (Grant No. 18-72-00052). The equipment of the Ural Center for Shared Use Modern nanotechnology UrFU was used. Computer simulation was performed under the support of Russian Foundation for Basic Research (Grant No. 19-01-00519A). X-ray diffraction data were collected under the experiment SC-4587 at the European Synchrotron Radiation Source (ESRF, Grenoble, France). S.K., P.Z., L.M., and A.K. are grateful to FCT project PTDC/CTM-CTM/31679/2017 (CENTRO-01-0145-FEDER-031679). P.Z. and L.M. are grateful to FCT project PTDC/QEQ: QAN/6373/2014. S.K and A.K were also supported by the joint Portugal -Turkey project (TUBITAK/0006/2014). Part of this work was developed within the scope of the project CICECO-Aveiro Institute of Materials, FCT ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree -Law 57/2016, of August 29, changed by Law 57/2017, of July 19.

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