abstract
Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.
keywords
GERANYLGERANIOL-DERIVED DITERPENES; BIOACTIVE COMPOUNDS; CRUDE EXTRACTS; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIFOULING ACTIVITY; PHENOLIC CONTENT; ALGA; ELEGANOLONE; CYSTOSEIRACEAE
subject category
Pharmacology & Pharmacy
authors
Pais, ACS; Saraiva, JA; Rocha, SM; Silvestre, AJD; Santos, SAO
our authors
Adriana Cabrita Sousa Pais
PhD Student
Armando Jorge Domingues Silvestre
Full professor
Sónia Andreia Oliveira Santos
Assistant ResearcherProjects
acknowledgements
This research was funded by the project AgroForWealth: Biorefining of agricultural and forest by-products and wastes: integrated strategic for valorization of resources towards society wealth and sustainability (CENTRO-01-0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, by FCT/MCTES which financed the project CICECO-Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and QOPNA research Unit (FCT UID/QUI/00062/2019).