Extraction of phenolic compounds from rosemary using choline chloride - based Deep Eutectic Solvents
authors Wojeicchowski, JP; Marques, C; Igarashi-Mafra, L; Coutinho, JAP; Mafra, MR
nationality International
journal SEPARATION AND PURIFICATION TECHNOLOGY
author keywords Solubility; Carnosic acid; Carnosol; Rosmarinic acid; COSMO-RS
keywords COSMO-RS; ANTIMICROBIAL ACTIVITIES; ASSISTED EXTRACTION; BIOACTIVE COMPOUNDS; IONIC LIQUIDS; CARNOSIC ACID; ANTIOXIDANT; ANTIBACTERIAL; CHEMISTRY; DESIGN
abstract Deep eutectic solvents (DES) have been explored as an alternative to hazardous solvents to extract natural bioactive compounds. In this work, choline chloride-based DES (neat and hydrated) were assessed in the extraction of phenolics from rosemary leaves. The DES studied on an initial screening showed a total phenolic content (TPC) up to 220% higher than the control. The solubilities of the main rosemary biocompounds, estimated by COSMO-RS, showed a positive correlation to TPC. Choline chloride:1,2-propanediol (CPH) was selected for further optimization. At the optimal conditions (65 degrees C, liquid: solid ratio of 40:1 and 50 %wt of water), the antioxidant activity and TPC were 80 mg of Trolox equivalent/g and 78 mg of gallic acid equivalent/g, respectively. The antimicrobial activity of the optimized extract revealed inhibition of 39-51% to all bacteria tested. In summary, an extract with good antioxidant and antimicrobial activities was obtained from rosemary leaves using CPH as solvent.
publisher ELSEVIER
issn 1383-5866
isbn 1873-3794
year published 2021
volume 258
digital object identifier (doi) 10.1016/j.seppur.2020.117975
web of science category 8
subject category Engineering, Chemical
unique article identifier WOS:000598152900006
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journal impact factor 5.774
5 year journal impact factor 5.257
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