First complete NMR data and theoretical study of an antimicrobial formylated dihydrochalcone from Psidium guineense Sw
authors Lima, EM; Fernando, LM; Felix, LP; de Oliveira, AA; Neto, ANC; Moura, RT; Teles, YCF
nationality International
journal NATURAL PRODUCT RESEARCH
author keywords 3 '-formyl-2 ',4 ',6 '-trihydroxy-5 '-methyldihydrochalcone; Psidium guineense Sw; Pseudomonas aeruginosa; DFT
keywords CHALCONE SCAFFOLD
abstract Chalcones are a widespread group of natural compounds characterized by the basic structure 1,3-diaryl-2-propen-1-one. In this study, we focused on the uncommon formylated chalcone 3'-formyl-2',4',6'-trihydroxy-5'-methyldihydrochalcone that possess interesting antimicrobial and anticancer potential. Considering the pharmacological relevance of this compound, we report its isolation and the first complete and unequivocal NMR data for this substance, corroborated by in silico theoretical study. In addition to that, its antibacterial potential was evaluated and the compound presented strong activity against Pseudomonas aeruginosa. [GRAPHICS] .
publisher TAYLOR & FRANCIS LTD
issn 1478-6419
isbn 1478-6427
year published 2021
volume 36
issue 1
beginning page 419
ending page 423
digital object identifier (doi) 10.1080/14786419.2020.1771709
web of science category 5
subject category Chemistry, Applied; Chemistry, Medicinal
unique article identifier WOS:000545136900001
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journal analysis (jcr 2019):
journal impact factor 2.158
5 year journal impact factor 1.885
category normalized journal impact factor percentile 46.029
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