First complete NMR data and theoretical study of an antimicrobial formylated dihydrochalcone from Psidium guineense Sw

authors	Lima, EM; Fernando, LM; Felix, LP; de Oliveira, AA; Neto, ANC; Moura, RT; Teles, YCF
nationality	International
journal	NATURAL PRODUCT RESEARCH
author keywords	3 '-formyl-2 ',4 ',6 '-trihydroxy-5 '-methyldihydrochalcone; Psidium guineense Sw; Pseudomonas aeruginosa; DFT
keywords	CHALCONE SCAFFOLD
abstract	Chalcones are a widespread group of natural compounds characterized by the basic structure 1,3-diaryl-2-propen-1-one. In this study, we focused on the uncommon formylated chalcone 3'-formyl-2',4',6'-trihydroxy-5'-methyldihydrochalcone that possess interesting antimicrobial and anticancer potential. Considering the pharmacological relevance of this compound, we report its isolation and the first complete and unequivocal NMR data for this substance, corroborated by in silico theoretical study. In addition to that, its antibacterial potential was evaluated and the compound presented strong activity against Pseudomonas aeruginosa. [GRAPHICS] .
publisher	TAYLOR & FRANCIS LTD
issn	1478-6419
isbn	1478-6427
year published	2021
volume	36
issue	1
beginning page	419
ending page	423
digital object identifier (doi)	10.1080/14786419.2020.1771709
web of science category	5
subject category	Chemistry, Applied; Chemistry, Medicinal
unique article identifier	WOS:000545136900001