Evaluating the hazardous impact of ionic liquids-Challenges and opportunities
authors Magina, S; Barros-Timmons, A; Ventura, SPM; Evtuguin, DV
nationality International
journal JOURNAL OF HAZARDOUS MATERIALS
author keywords Ionic liquid; Phytotoxicity; Cytotoxicity; Enzymatic inhibition; Biodegradability; Toxicity modeling
keywords ADVANCED OXIDATION PROCESSES; OF-THE-ART; FUNCTIONALIZED SIDE-CHAINS; WHEAT TRITICUM-AESTIVUM; ZEBRAFISH DANIO-RERIO; PHYSICOCHEMICAL PROPERTIES; 1-BUTYL-3-METHYLIMIDAZOLIUM CHLORIDE; ACUTE TOXICITY; DIFFERENT ANIONS; THERMOPHYSICAL PROPERTIES
abstract Ionic liquids (ILs), being related to the design of new environmentally friendly solvents, are widely considered for applications within the ?green chemistry? concept. Due to their unique properties and wide diversity, ILs allow tailoring new separation procedures and producing new materials for advanced applications. However, despite the promising technical performance, environmental concerns highlighted in recent studies focused on the toxicity and biodegradability of ILs and their metabolites have revealed that ILs safety labels are not as benign as previously claimed. This review refers to the fundamentals about the properties and applications of ILs also in the context of their potential environmental effect. Toxicological issues and harmful effects related to the use of ILs are discussed, including the evaluation of their biodegradability and ecological impact on diverse organisms and ecosystems, also with respect to bacteria, fungi, and cell cultures. In addition, this review covers the tools used to assess the toxicity of ILs, including the predictive computational models and the results of studies involving cell membrane models and molecular simulations. Summing up the knowledge available so far, there are still no reliable criteria for unequivocal attribution of toxicity and environmental impact credentials for ILs, which is a challenging research task.
publisher ELSEVIER
issn 0304-3894
isbn 1873-3336
year published 2021
volume 412
digital object identifier (doi) 10.1016/j.jhazmat.2021.125215
web of science category 26
subject category Engineering, Environmental; Environmental Sciences
unique article identifier WOS:000647494800006
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5 year journal impact factor 8.512
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